IL2RA
Summary: The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:147730 Ensembl IDEnsembl:ENSG00000134460 HGNC IDHGNC:HGNC:6008 PHARMGKB IDPA29828 Map Location10p15.1 | |||||
GO terms in IL2RA
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0002437 | inflammatory response to antigenic stimulus |
| BP | IMP | GO:0002664 | regulation of T cell tolerance induction |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IEA | GO:0006924 | activation-induced cell death of T cells |
| BP | IBA | GO:0006954 | inflammatory response |
Gene expression in normal tissue: IL2RA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL2RA
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | il2pathway | il 2 signaling pathway |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL2RA
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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