Summary: The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009].

interleukin 2 receptor subunit alphaMIM:147730Ensembl:ENSG00000134460HGNC:HGNC:6008PA2982810p15.1

GO terms in IL2RA

Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0000165MAPK cascade
BPIEAGO:0002437inflammatory response to antigenic stimulus
BPIMPGO:0002664regulation of T cell tolerance induction
BPTASGO:0006915apoptotic process
BPIEAGO:0006924activation-induced cell death of T cells
BPIBAGO:0006954inflammatory response
BPTASGO:0006955immune response
BPTASGO:0007166cell surface receptor signaling pathway
BPIEAGO:0007219Notch signaling pathway
BPTASGO:0008283cell proliferation
BPTASGO:0019221cytokine-mediated signaling pathway
BPTASGO:0038110interleukin-2-mediated signaling pathway
BPIEAGO:0042104positive regulation of activated T cell proliferation
BPIEAGO:0042130negative regulation of T cell proliferation
BPIEAGO:0045582positive regulation of T cell differentiation
BPTASGO:0045589regulation of regulatory T cell differentiation
BPIEAGO:0046013regulation of T cell homeostatic proliferation
BPIEAGO:0050687negative regulation of defense response to virus
BPIEAGO:0050728negative regulation of inflammatory response
BPIEAGO:0050777negative regulation of immune response
CCTASGO:0005886plasma membrane
CCIEAGO:0009897external side of plasma membrane
CCIEAGO:0016021integral component of membrane
MFIBAGO:0004911interleukin-2 receptor activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIPIGO:0005515protein binding
MFIEAGO:0008144drug binding
MFIBAGO:0019976interleukin-2 binding

Gene expression in normal tissue: IL2RA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IL2RA

DatabasePathway IDPathway Des.
biocartail2pathwayil 2 signaling pathway
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-451927Interleukin-2 family signaling
reactomeR-HSA-512988Interleukin-3, Interleukin-5 and GM-CSF signaling
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8877330RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-9020558Interleukin-2 signaling
reactomeR-HSA-912526Interleukin receptor SHC signaling
wikipathwaysWP205IL-7 Signaling Pathway
wikipathwaysWP2203Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathwaysWP2328Allograft Rejection
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4079RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP453Inflammatory Response Pathway
wikipathwaysWP49IL-2 Signaling Pathway
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04640Hematopoietic cell lineage - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
pidcd8tcrdownstreampathwayDownstream signaling in naïve CD8+ T cells
pidil12_2pathwayIL12-mediated signaling events
pidil12_stat4pathwayIL12 signaling mediated by STAT4
pidil2_1pathwayIL2-mediated signaling events
pidil2_pi3kpathwayIL2 signaling events mediated by PI3K
pidil2_stat5pathwayIL2 signaling events mediated by STAT5
pidnfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
pidshp2_pathwaySHP2 signaling
pidtcrcalciumpathwayCalcium signaling in the CD4+ TCR pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD85Ursolic acid3
iGMDRD512nutlin 33

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IL2RA