ZMAT3
Summary: This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| zinc finger matrin-type 3 | MIM:606452 | Ensembl:ENSG00000172667 | HGNC:HGNC:29983 | PA145147560 | 3q26.32 |
GO terms in ZMAT3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IEA | GO:0015031 | protein transport |
| BP | IEA | GO:0040008 | regulation of growth |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005886 | plasma membrane |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
Gene expression in normal tissue: ZMAT3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZMAT3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3982 | miRNA regulation of p53 pathway in prostate cancer |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ZMAT3
CLASSFICATION
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