TACC3


Summary: This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
transforming acidic coiled-coil containing protein 3MIM:605303Ensembl:ENSG00000013810HGNC:HGNC:11524PA363014p16.3

Gene Categories:

TUMOR SUPPRESSOR

GO terms in TACC3


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0000226microtubule cytoskeleton organization
BPIMPGO:0007091metaphase/anaphase transition of mitotic cell cycle
BPIBAGO:0008283cell proliferation
BPIBAGO:0021987cerebral cortex development
BPIEAGO:0051301cell division
BPIMPGO:0060236regulation of mitotic spindle organization
BPIMPGO:1902850microtubule cytoskeleton organization involved in mitosis
CCIEAGO:0000922spindle pole
CCIBAGO:0005737cytoplasm
CCIDAGO:0005815microtubule organizing center
CCIDAGO:0005829cytosol
CCIDAGO:0072686mitotic spindle
MFIPIGO:0005515protein binding

Gene expression in normal tissue: TACC3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TACC3


DatabasePathway IDPathway Des.
kegghsa03013RNA transport - Homo sapiens (human)
pidaurora_a_pathwayAurora A signaling
pidilk_pathwayIntegrin-linked kinase signaling
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-9012852Signaling by NOTCH3
reactomeR-HSA-9013507NOTCH3 Activation and Transmission of Signal to the Nucleus
reactomeR-HSA-9013694Signaling by NOTCH4
reactomeR-HSA-9604323Negative regulation of NOTCH4 signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD945ML2143
iGMDRD451Serdemetan3
iGMDRD280CYTOCHALASIN B1
iGMDRD60Quinoclamine5
iGMDRD300Tozasertib4
iGMDRD297Austocystin D2
iGMDRD314Tanespimycin5
iGMDRD872BRD71373
iGMDRD871BRD63683
iGMDRD546BMS-7548071
iGMDRD434BMS-5369243
iGMDRD289Parthenolide1
iGMDRD248BRD43543
iGMDRD512nutlin 33

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TACC3

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