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TACC3

Summary: This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nametransforming acidic coiled-coil containing protein 3 OMIM IDMIM:605303 Ensembl IDEnsembl:ENSG00000013810 HGNC IDHGNC:HGNC:11524 PHARMGKB IDPA36301 Map Location4p16.3

Gene Categories:

TUMOR SUPPRESSOR

GO terms in TACC3

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0000226	microtubule cytoskeleton organization
BP	IMP	GO:0007091	metaphase/anaphase transition of mitotic cell cycle
BP	IBA	GO:0008283	cell proliferation
BP	IBA	GO:0021987	cerebral cortex development
BP	IEA	GO:0051301	cell division
BP	IMP	GO:0060236	regulation of mitotic spindle organization

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Gene expression in normal tissue: TACC3

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TACC3

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Database	Pathway ID	Pathway Des.
kegg	hsa03013	RNA transport - Homo sapiens (human)
pid	aurora_a_pathway	Aurora A signaling
pid	ilk_pathway	Integrin-linked kinase signaling
reactome	R-HSA-157118	Signaling by NOTCH
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-9012852	Signaling by NOTCH3

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD945	ML214	3
iGMDRD451	Serdemetan	3
iGMDRD280	CYTOCHALASIN B	1
iGMDRD60	Quinoclamine	5

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TACC3

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

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