TACC3
Summary: This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transforming acidic coiled-coil containing protein 3 | MIM:605303 | Ensembl:ENSG00000013810 | HGNC:HGNC:11524 | PA36301 | 4p16.3 |
Gene Categories:
TUMOR SUPPRESSORGO terms in TACC3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000226 | microtubule cytoskeleton organization |
| BP | IMP | GO:0007091 | metaphase/anaphase transition of mitotic cell cycle |
| BP | IBA | GO:0008283 | cell proliferation |
| BP | IBA | GO:0021987 | cerebral cortex development |
| BP | IEA | GO:0051301 | cell division |
| BP | IMP | GO:0060236 | regulation of mitotic spindle organization |
| BP | IMP | GO:1902850 | microtubule cytoskeleton organization involved in mitosis |
| CC | IEA | GO:0000922 | spindle pole |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005815 | microtubule organizing center |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0072686 | mitotic spindle |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: TACC3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TACC3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03013 | RNA transport - Homo sapiens (human) |
| pid | aurora_a_pathway | Aurora A signaling |
| pid | ilk_pathway | Integrin-linked kinase signaling |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus |
| reactome | R-HSA-9013694 | Signaling by NOTCH4 |
| reactome | R-HSA-9604323 | Negative regulation of NOTCH4 signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD945 | ML214 | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD60 | Quinoclamine | 5 |
| iGMDRD300 | Tozasertib | 4 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD314 | Tanespimycin | 5 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD248 | BRD4354 | 3 |
| iGMDRD512 | nutlin 3 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TACC3
CLASSFICATION
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