NFE2L2
Summary: This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nuclear factor, erythroid 2 like 2 | MIM:600492 | Ensembl:ENSG00000116044 | HGNC:HGNC:7782 | PA31588 | 2q31.2 |
GO terms in NFE2L2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000785 | chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | ISS | GO:0032993 | protein-DNA complex |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | IEA | GO:0007568 | aging |
| BP | IDA | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process |
| BP | IGI | GO:0010628 | positive regulation of gene expression |
| BP | IEA | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process |
| BP | IEA | GO:0010976 | positive regulation of neuron projection development |
| BP | IDA | GO:0016567 | protein ubiquitination |
| BP | IEA | GO:0030194 | positive regulation of blood coagulation |
| BP | ISS | GO:0030968 | endoplasmic reticulum unfolded protein response |
| BP | IBA | GO:0034599 | cellular response to oxidative stress |
| BP | NAS | GO:0034599 | cellular response to oxidative stress |
| BP | TAS | GO:0034599 | cellular response to oxidative stress |
| BP | IMP | GO:0036003 | positive regulation of transcription from RNA polymerase II promoter in response to stress |
| BP | IEA | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress |
| BP | ISS | GO:0036499 | PERK-mediated unfolded protein response |
| BP | TAS | GO:0036499 | PERK-mediated unfolded protein response |
| BP | IEA | GO:0042149 | cellular response to glucose starvation |
| BP | IDA | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| BP | IEA | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| BP | IEA | GO:0045454 | cell redox homeostasis |
| BP | IEA | GO:0045766 | positive regulation of angiogenesis |
| BP | IBA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IC | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0045995 | regulation of embryonic development |
| BP | IEA | GO:0046223 | aflatoxin catabolic process |
| BP | IEA | GO:0046326 | positive regulation of glucose import |
| BP | IMP | GO:0061419 | positive regulation of transcription from RNA polymerase II promoter in response to hypoxia |
| BP | IMP | GO:0070301 | cellular response to hydrogen peroxide |
| BP | IMP | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IDA | GO:0071498 | cellular response to fluid shear stress |
| BP | IMP | GO:0071499 | cellular response to laminar fluid shear stress |
| BP | IEA | GO:1902037 | negative regulation of hematopoietic stem cell differentiation |
| BP | IMP | GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| BP | TAS | GO:1903071 | positive regulation of ER-associated ubiquitin-dependent protein catabolic process |
| BP | IGI | GO:1903206 | negative regulation of hydrogen peroxide-induced cell death |
| BP | IEA | GO:1903788 | positive regulation of glutathione biosynthetic process |
| BP | IEA | GO:1904385 | cellular response to angiotensin |
| BP | IEA | GO:1904753 | negative regulation of vascular associated smooth muscle cell migration |
| BP | IEA | GO:2000121 | regulation of removal of superoxide radicals |
| BP | IMP | GO:2000352 | negative regulation of endothelial cell apoptotic process |
| BP | IEA | GO:2000379 | positive regulation of reactive oxygen species metabolic process |
| MF | IBA | GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| MF | TAS | GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| MF | IEA | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IPI | GO:0001102 | RNA polymerase II activating transcription factor binding |
| MF | IEA | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | IEA | GO:0001221 | transcription cofactor binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | TAS | GO:0044212 | transcription regulatory region DNA binding |
Gene expression in normal tissue: NFE2L2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NFE2L2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| wikipathways | WP2435 | Quercetin and Nf-kB- AP-1 Induced Cell Apoptosis |
| wikipathways | WP2586 | Aryl Hydrocarbon Receptor |
| wikipathways | WP28 | Selenium Metabolism and Selenoproteins |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP2873 | Aryl Hydrocarbon Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| wikipathways | WP3 | Transcriptional activation by NRF2 |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP3612 | Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling |
| wikipathways | WP3613 | Photodynamic therapy-induced unfolded protein response |
| wikipathways | WP3624 | Lung fibrosis |
| wikipathways | WP3670 | Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway |
| wikipathways | WP408 | Oxidative Stress |
| wikipathways | WP4206 | Hereditary Leiomyomatosis and Renal Cell Carcinoma Pathway |
| biocarta | arenrf2pathway | oxidative stress induced gene expression via nrf2 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD316 | N9-Isopropyl-olomoucine | 1 |
| iGMDRD851 | BRD-K34222889 | 2 |
| iGMDRD141 | NSC48300 | 2 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD472 | PF-562271 | 1 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD746 | CDK9 Inhibitor | 1 |
| iGMDRD148 | Pifithrin-mu | 1 |
| iGMDRD404 | PD318088 | 1 |
| iGMDRD206 | SJ-172550 | 2 |
| iGMDRD372 | TGX 221 | 1 |
| iGMDRD546 | BMS-754807 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NFE2L2
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.