NFE2L2

Summary: This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namenuclear factor, erythroid 2 like 2
OMIM IDMIM:600492
Ensembl IDEnsembl:ENSG00000116044
HGNC IDHGNC:HGNC:7782
PHARMGKB IDPA31588
Map Location2q31.2

GO terms in NFE2L2


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IEA GO:0000785 chromatin
CC IBA GO:0005634 nucleus
CC IDA GO:0005634 nucleus
CC IDA GO:0005654 nucleoplasm
CC IBA GO:0005737 cytoplasm
CC IDA GO:0005737 cytoplasm
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Gene expression in normal tissue: NFE2L2

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 8undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 7STOMACtissue: STOMAC cancer: STOMACH model num: 0STOMACHtissue: STOMACH cancer: Esophageal Adenocarcinoma (ESCA) model num: 1

Gene-drug pathway distribution

undefined8IGFR signaling1PI3K/MTOR signaling1Cell cycle1Cytoskeleton1ERK MAPK signaling1

Pathways in NFE2L2


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Database
Pathway ID
Pathway Des.
kegg hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegg hsa05200 Pathways in cancer - Homo sapiens (human)
kegg hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
kegg hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)
wikipathways WP2435 Quercetin and Nf-kB- AP-1 Induced Cell Apoptosis
wikipathways WP2586 Aryl Hydrocarbon Receptor
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD316 N9-Isopropyl-olomoucine 1
iGMDRD851 BRD-K34222889 2
iGMDRD141 NSC48300 2
iGMDRD188 Piperlongumine 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NFE2L2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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