RBM10
Summary: This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RNA binding motif protein 10 | MIM:300080 | Ensembl:ENSG00000182872 | HGNC:HGNC:9896 | PA34259 | Xp11.3 |
GO terms in RBM10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0016607 | nuclear speck |
| BP | IEA | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
| BP | IEA | GO:0006397 | mRNA processing |
| BP | ND | GO:0008150 | biological_process |
| BP | IEA | GO:0008380 | RNA splicing |
| BP | IEA | GO:0042981 | regulation of apoptotic process |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0035198 | miRNA binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0044877 | protein-containing complex binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: RBM10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RBM10
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD399 | Selumetinib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RBM10
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.