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PTK2B

Summary: This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
protein tyrosine kinase 2 beta	MIM:601212	Ensembl:ENSG00000120899	HGNC:HGNC:9612	PA33956	8p21.2

Gene Categories:

KINASE ION CHANNEL LIPID KINASE TYROSINE KINASE DRUG RESISTANCE SERINE THREONINE KINASE DRUGGABLE GENOME TRANSPORTER

GO terms in PTK2B

Term Type	Evidence Type	GO Term ID	GO Des.
MF	ISS	GO:0004683	calmodulin-dependent protein kinase activity
MF	IDA	GO:0004713	protein tyrosine kinase activity
MF	IBA	GO:0004715	non-membrane spanning protein tyrosine kinase activity
MF	IDA	GO:0004715	non-membrane spanning protein tyrosine kinase activity
MF	ISS	GO:0004972	NMDA glutamate receptor activity
MF	IBA	GO:0005102	signaling receptor binding
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	IMP	GO:0008022	protein C-terminus binding
MF	IEA	GO:0031625	ubiquitin protein ligase binding
MF	IEA	GO:0043423	3-phosphoinositide-dependent protein kinase binding
MF	IEA	GO:0044877	protein-containing complex binding
BP	IEA	GO:0000165	MAPK cascade
BP	IBA	GO:0001525	angiogenesis
BP	IEA	GO:0001556	oocyte maturation
BP	IEA	GO:0001666	response to hypoxia
BP	IMP	GO:0001954	positive regulation of cell-matrix adhesion
BP	ISS	GO:0002040	sprouting angiogenesis
BP	IEA	GO:0002250	adaptive immune response
BP	ISS	GO:0002315	marginal zone B cell differentiation
BP	TAS	GO:0006468	protein phosphorylation
BP	TAS	GO:0006915	apoptotic process
BP	ISS	GO:0006968	cellular defense response
BP	IEA	GO:0006970	response to osmotic stress
BP	TAS	GO:0007165	signal transduction
BP	IMP	GO:0007166	cell surface receptor signaling pathway
BP	IBA	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
BP	IEA	GO:0007172	signal complex assembly
BP	IBA	GO:0007173	epidermal growth factor receptor signaling pathway
BP	IEA	GO:0007204	positive regulation of cytosolic calcium ion concentration
BP	IMP	GO:0007229	integrin-mediated signaling pathway
BP	IMP	GO:0008284	positive regulation of cell proliferation
BP	IMP	GO:0008285	negative regulation of cell proliferation
BP	IMP	GO:0008360	regulation of cell shape
BP	IEA	GO:0009612	response to mechanical stimulus
BP	IEA	GO:0009725	response to hormone
BP	IEA	GO:0009749	response to glucose
BP	IEA	GO:0010226	response to lithium ion
BP	IDA	GO:0010595	positive regulation of endothelial cell migration
BP	IEA	GO:0010656	negative regulation of muscle cell apoptotic process
BP	IEA	GO:0010752	regulation of cGMP-mediated signaling
BP	ISS	GO:0010758	regulation of macrophage chemotaxis
BP	IMP	GO:0010976	positive regulation of neuron projection development
BP	IEA	GO:0014009	glial cell proliferation
BP	IDA	GO:0018108	peptidyl-tyrosine phosphorylation
BP	IBA	GO:0030154	cell differentiation
BP	IBA	GO:0030155	regulation of cell adhesion
BP	IMP	GO:0030155	regulation of cell adhesion
BP	IEA	GO:0030307	positive regulation of cell growth
BP	IMP	GO:0030335	positive regulation of cell migration
BP	ISS	GO:0030502	negative regulation of bone mineralization
BP	IMP	GO:0030838	positive regulation of actin filament polymerization
BP	IEA	GO:0031175	neuron projection development
BP	ISS	GO:0032960	regulation of inositol trisphosphate biosynthetic process
BP	IMP	GO:0033209	tumor necrosis factor-mediated signaling pathway
BP	ISS	GO:0035235	ionotropic glutamate receptor signaling pathway
BP	IEA	GO:0035902	response to immobilization stress
BP	IBA	GO:0038083	peptidyl-tyrosine autophosphorylation
BP	IDA	GO:0038083	peptidyl-tyrosine autophosphorylation
BP	ISS	GO:0038083	peptidyl-tyrosine autophosphorylation
BP	TAS	GO:0038110	interleukin-2-mediated signaling pathway
BP	IBA	GO:0042127	regulation of cell proliferation
BP	IEA	GO:0042220	response to cocaine
BP	IEA	GO:0042542	response to hydrogen peroxide
BP	IMP	GO:0042976	activation of Janus kinase activity
BP	IMP	GO:0043066	negative regulation of apoptotic process
BP	IEA	GO:0043149	stress fiber assembly
BP	IDA	GO:0043267	negative regulation of potassium ion transport
BP	IEA	GO:0043507	positive regulation of JUN kinase activity
BP	ISS	GO:0043524	negative regulation of neuron apoptotic process
BP	IEA	GO:0043534	blood vessel endothelial cell migration
BP	ISS	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
BP	IBA	GO:0045087	innate immune response
BP	IEA	GO:0045429	positive regulation of nitric oxide biosynthetic process
BP	ISS	GO:0045453	bone resorption
BP	IEA	GO:0045471	response to ethanol
BP	IMP	GO:0045638	negative regulation of myeloid cell differentiation
BP	IEA	GO:0045727	positive regulation of translation
BP	IEA	GO:0045766	positive regulation of angiogenesis
BP	IMP	GO:0045860	positive regulation of protein kinase activity
BP	IMP	GO:0046330	positive regulation of JNK cascade
BP	TAS	GO:0046777	protein autophosphorylation
BP	IMP	GO:0048010	vascular endothelial growth factor receptor signaling pathway
BP	TAS	GO:0048010	vascular endothelial growth factor receptor signaling pathway
BP	IEA	GO:0048041	focal adhesion assembly
BP	TAS	GO:0048167	regulation of synaptic plasticity
BP	IDA	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
BP	IEA	GO:0050848	regulation of calcium-mediated signaling
BP	IEA	GO:0051000	positive regulation of nitric-oxide synthase activity
BP	ISS	GO:0051279	regulation of release of sequestered calcium ion into cytosol
BP	IEA	GO:0051591	response to cAMP
BP	IEA	GO:0051592	response to calcium ion
BP	ISS	GO:0051968	positive regulation of synaptic transmission, glutamatergic
BP	ISS	GO:0060291	long-term synaptic potentiation
BP	IEA	GO:0060292	long term synaptic depression
BP	TAS	GO:0065003	protein-containing complex assembly
BP	ISS	GO:0070098	chemokine-mediated signaling pathway
BP	IMP	GO:0070374	positive regulation of ERK1 and ERK2 cascade
BP	IMP	GO:0071300	cellular response to retinoic acid
BP	IEA	GO:0071498	cellular response to fluid shear stress
BP	IEA	GO:0090630	activation of GTPase activity
BP	IDA	GO:2000058	regulation of ubiquitin-dependent protein catabolic process
BP	IEA	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process
BP	ISS	GO:2000114	regulation of establishment of cell polarity
BP	ISS	GO:2000249	regulation of actin cytoskeleton reorganization
BP	ISS	GO:2000310	regulation of NMDA receptor activity
BP	ISS	GO:2000463	positive regulation of excitatory postsynaptic potential
BP	ISS	GO:2000538	positive regulation of B cell chemotaxis
BP	IEA	GO:2000573	positive regulation of DNA biosynthetic process
CC	IDA	GO:0005634	nucleus
CC	TAS	GO:0005737	cytoplasm
CC	TAS	GO:0005829	cytosol
CC	IEA	GO:0005856	cytoskeleton
CC	IBA	GO:0005925	focal adhesion
CC	IDA	GO:0005925	focal adhesion
CC	IEA	GO:0005938	cell cortex
CC	ISS	GO:0014069	postsynaptic density
CC	TAS	GO:0014069	postsynaptic density
CC	ISS	GO:0017146	NMDA selective glutamate receptor complex
CC	IDA	GO:0030027	lamellipodium
CC	ISS	GO:0030425	dendrite
CC	ISS	GO:0030426	growth cone
CC	IBA	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
CC	ISS	GO:0043025	neuronal cell body
CC	IBA	GO:0043197	dendritic spine
CC	IEA	GO:0043197	dendritic spine
CC	ISS	GO:0044297	cell body
CC	IEA	GO:0045121	membrane raft
CC	IDA	GO:0048471	perinuclear region of cytoplasm
CC	ISS	GO:0097440	apical dendrite

Gene expression in normal tissue: PTK2B

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PTK2B

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-1500931	Cell-Cell communication
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-168256	Immune System
reactome	R-HSA-194138	Signaling by VEGF
reactome	R-HSA-391160	Signal regulatory protein family interactions
reactome	R-HSA-4420097	VEGFA-VEGFR2 Pathway
reactome	R-HSA-449147	Signaling by Interleukins
reactome	R-HSA-451927	Interleukin-2 family signaling
reactome	R-HSA-9006934	Signaling by Receptor Tyrosine Kinases
reactome	R-HSA-9020558	Interleukin-2 signaling
biocarta	achpathway	role of nicotinic acetylcholine receptors in the regulation of apoptosis
biocarta	at1rpathway	angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling
biocarta	biopeptidespathway	bioactive peptide induced signaling pathway
biocarta	hbxpathway	calcium signaling by hbx of hepatitis b virus
biocarta	il7pathway	il-7 signal transduction
biocarta	par1pathway	thrombin signaling and protease-activated receptors
biocarta	pyk2pathway	links between pyk2 and map kinases
kegg	hsa04020	Calcium signaling pathway - Homo sapiens (human)
kegg	hsa04062	Chemokine signaling pathway - Homo sapiens (human)
kegg	hsa04072	Phospholipase D signaling pathway - Homo sapiens (human)
kegg	hsa04650	Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegg	hsa04670	Leukocyte transendothelial migration - Homo sapiens (human)
kegg	hsa04912	GnRH signaling pathway - Homo sapiens (human)
kegg	hsa05161	Hepatitis B - Homo sapiens (human)
pid	alphasynuclein_pathway	Alpha-synuclein signaling
pid	ar_pathway	Coregulation of Androgen receptor activity
pid	avb3_integrin_pathway	Integrins in angiogenesis
pid	avb3_opn_pathway	Osteopontin-mediated events
pid	cxcr4_pathway	CXCR4-mediated signaling events
pid	endothelinpathway	Endothelins
pid	fgf_pathway	FGF signaling pathway
pid	il2_1pathway	IL2-mediated signaling events
pid	integrin_a4b1_pathway	Alpha4 beta1 integrin signaling events
pid	lysophospholipid_pathway	LPA receptor mediated events
pid	vegfr1_2_pathway	Signaling events mediated by VEGFR1 and VEGFR2
netpath	Pathway_BCR	BCR
netpath	Pathway_BDNF	BDNF
netpath	Pathway_EGFR1	EGFR1
netpath	Pathway_IL-7	IL-7
netpath	Pathway_IL2	IL2
netpath	Pathway_IL5	IL5
netpath	Pathway_IL6	IL6
netpath	Pathway_Oncostatin_M	Oncostatin_M
netpath	Pathway_TCR	TCR
wikipathways	WP205	IL-7 Signaling Pathway
wikipathways	WP2263	Androgen Receptor Network in Prostate Cancer
wikipathways	WP2374	Oncostatin M Signaling Pathway
wikipathways	WP2380	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathways	WP259	Nifedipine Activity
wikipathways	WP2864	Apoptosis-related network due to altered Notch3 in ovarian cancer
wikipathways	WP313	Signaling of Hepatocyte Growth Factor Receptor
wikipathways	WP3888	VEGFA-VEGFR2 Signaling Pathway
wikipathways	WP3929	Chemokine signaling pathway
wikipathways	WP437	EGF-EGFR Signaling Pathway
wikipathways	WP49	IL-2 Signaling Pathway
wikipathways	WP69	T-Cell antigen Receptor (TCR) Signaling Pathway

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD210	AC55649	1
iGMDRD231	Importazole	2
iGMDRD441	TW 37	3
iGMDRD434	BMS-536924	3
iGMDRD546	BMS-754807	3
iGMDRD105	Triptolide	5
iGMDRD577	BIX01294	1
iGMDRD414	MST-312	3
iGMDRD945	ML214	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PTK2B

SITE

DATATYPES

CLASSFICATION

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