AKAP14
Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The protein anchors PKA in ciliary axonemes and, in this way, may play a role in regulating ciliary beat frequency. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:300462 Ensembl IDEnsembl:ENSG00000186471 HGNC IDHGNC:HGNC:24061 PHARMGKB IDPA134914893 Map LocationXq24 | |||||
GO terms in AKAP14
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005930 | axoneme |
| CC | IBA | GO:0005952 | cAMP-dependent protein kinase complex |
| CC | IMP | GO:0005952 | cAMP-dependent protein kinase complex |
| BP | ND | GO:0008150 | biological_process |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0034237 | protein kinase A regulatory subunit binding |
Gene expression in normal tissue: AKAP14
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AKAP14
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD399 | Selumetinib | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AKAP14
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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