LRRC2
Summary: This gene encodes a member of the leucine-rich repeat-containing family of proteins, which function in diverse biological pathways. This family member may possibly be a nuclear protein. Similarity to the RAS suppressor protein, as well as expression down-regulation observed in tumor cells, suggests that it may function as a tumor suppressor. The gene is located in the chromosome 3 common eliminated region 1 (C3CER1), a 1.4 Mb region that is commonly deleted in diverse tumors. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Sep 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| leucine rich repeat containing 2 | MIM:607180 | Ensembl:ENSG00000163827 | HGNC:HGNC:14676 | PA30461 | 3p21.31 |
GO terms in LRRC2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|
Gene expression in normal tissue: LRRC2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LRRC2
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD484 | Pluripotin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LRRC2
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