TAF6
Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TATA-box binding protein associated factor 6 | MIM:602955 | Ensembl:ENSG00000106290 | HGNC:HGNC:11540 | PA36315 | 7q22.1 |
GO terms in TAF6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0001102 | RNA polymerase II activating transcription factor binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0017162 | aryl hydrocarbon receptor binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| CC | IBA | GO:0000124 | SAGA complex |
| CC | IEA | GO:0000124 | SAGA complex |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005669 | transcription factor TFIID complex |
| CC | IDA | GO:0005669 | transcription factor TFIID complex |
| CC | IDA | GO:0005829 | cytosol |
| CC | IMP | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0033276 | transcription factor TFTC complex |
| CC | IEA | GO:0046695 | SLIK (SAGA-like) complex |
| CC | IDA | GO:0071339 | MLL1 complex |
| BP | IBA | GO:0006325 | chromatin organization |
| BP | IDA | GO:0006352 | DNA-templated transcription, initiation |
| BP | IBA | GO:0006366 | transcription by RNA polymerase II |
| BP | NAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | IDA | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | TAS | GO:0042795 | snRNA transcription by RNA polymerase II |
| BP | IDA | GO:0045786 | negative regulation of cell cycle |
| BP | IEA | GO:0051090 | regulation of DNA-binding transcription factor activity |
| BP | IBA | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly |
| BP | TAS | GO:1901796 | regulation of signal transduction by p53 class mediator |
Gene expression in normal tissue: TAF6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TAF6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-167161 | HIV Transcription Initiation |
| reactome | R-HSA-167162 | RNA Polymerase II HIV Promoter Escape |
| reactome | R-HSA-167172 | Transcription of the HIV genome |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-674695 | RNA Polymerase II Pre-transcription Events |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-6807505 | RNA polymerase II transcribes snRNA genes |
| reactome | R-HSA-6807505 | RNA polymerase II transcribes snRNA genes |
| reactome | R-HSA-73776 | RNA Polymerase II Promoter Escape |
| reactome | R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75953 | RNA Polymerase II Transcription Initiation |
| reactome | R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
| wikipathways | WP405 | Eukaryotic Transcription Initiation |
| kegg | hsa03022 | Basal transcription factors - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TAF6
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