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ZNF157

Summary: This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
zinc finger protein 157	MIM:300024	Ensembl:ENSG00000147117	HGNC:HGNC:12942	PA37525	Xp11.3

GO terms in ZNF157

Term Type	Evidence Type	GO Term ID	GO Des.
BP	TAS	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	IEA	GO:0006351	transcription, DNA-templated
CC	IEA	GO:0005634	nucleus
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	NAS	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IEA	GO:0003677	DNA binding
MF	TAS	GO:0003700	DNA-binding transcription factor activity
MF	IEA	GO:0046872	metal ion binding

Gene expression in normal tissue: ZNF157

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ZNF157

Database	Pathway ID	Pathway Des.
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-74160	Gene expression (Transcription)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	2
iGMDRD309	17AAG	1
iGMDRD399	Selumetinib	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ZNF157

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