CUL2
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cullin 2 | MIM:603135 | Ensembl:ENSG00000108094 | HGNC:HGNC:2552 | PA27048 | 10p11.21 |
Gene Categories:
TUMOR SUPPRESSORGO terms in CUL2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IEA | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | TAS | GO:0007050 | cell cycle arrest |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0016032 | viral process |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | TAS | GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia |
| BP | TAS | GO:0097193 | intrinsic apoptotic signaling pathway |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005730 | nucleolus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0030891 | VCB complex |
| CC | IBA | GO:0031461 | cullin-RING ubiquitin ligase complex |
| CC | IBA | GO:0031462 | Cul2-RING ubiquitin ligase complex |
| CC | IDA | GO:0031462 | Cul2-RING ubiquitin ligase complex |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0031625 | ubiquitin protein ligase binding |
| MF | IDA | GO:0031625 | ubiquitin protein ligase binding |
| MF | IEA | GO:0044877 | protein-containing complex binding |
| MF | IBA | GO:0061630 | ubiquitin protein ligase activity |
Gene expression in normal tissue: CUL2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CUL2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1234174 | Regulation of Hypoxia-inducible Factor (HIF) by oxygen |
| reactome | R-HSA-1234174 | Regulation of Hypoxia-inducible Factor (HIF) by oxygen |
| reactome | R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
| reactome | R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-2262749 | Cellular response to hypoxia |
| reactome | R-HSA-2262749 | Cellular response to hypoxia |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8951664 | Neddylation |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9010553 | Regulation of expression of SLITs and ROBOs |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| pid | hif1apathway | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| wikipathways | WP4241 | Type 2 papillary renal cell carcinoma |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 1 |
| iGMDRD262 | KU-55933 | 1 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD347 | Y-39983 | 1 |
| iGMDRD507 | GSK690693 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CUL2
CLASSFICATION
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