SAP30


Summary: Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
Sin3A associated protein 30MIM:603378Ensembl:ENSG00000164105HGNC:HGNC:10532PA349414q34.1

Gene Categories:

HISTONE MODIFICATION

GO terms in SAP30


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0006351transcription, DNA-templated
BPIBAGO:0006355regulation of transcription, DNA-templated
BPIDAGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0016575histone deacetylation
BPIEAGO:0035914skeletal muscle cell differentiation
CCIBAGO:0000118histone deacetylase complex
CCIDAGO:0000118histone deacetylase complex
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
MFIEAGO:0003677DNA binding
MFIBAGO:0003712transcription coregulator activity
MFIDAGO:0003714transcription corepressor activity
MFIBAGO:0004407histone deacetylase activity
MFTASGO:0004407histone deacetylase activity
MFIPIGO:0005515protein binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: SAP30

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SAP30


DatabasePathway IDPathway Des.
reactomeR-HSA-212165Epigenetic regulation of gene expression
reactomeR-HSA-3214815HDACs deacetylate histones
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-427413NoRC negatively regulates rRNA expression
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-5250941Negative epigenetic regulation of rRNA expression
reactomeR-HSA-74160Gene expression (Transcription)
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP61Notch Signaling Pathway
netpathPathway_NotchNotch
pidhdac_classi_pathwaySignaling events mediated by HDAC Class I
pidhedgehog_glipathwayHedgehog signaling events mediated by Gli proteins
pidsmad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
pidtelomerasepathwayRegulation of Telomerase

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD399Selumetinib2
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SAP30

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