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SAP30

Summary: Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameSin3A associated protein 30 OMIM IDMIM:603378 Ensembl IDEnsembl:ENSG00000164105 HGNC IDHGNC:HGNC:10532 PHARMGKB IDPA34941 Map Location4q34.1

Gene Categories:

HISTONE MODIFICATION

GO terms in SAP30

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	IEA	GO:0006351	transcription, DNA-templated
BP	IBA	GO:0006355	regulation of transcription, DNA-templated
BP	IDA	GO:0006355	regulation of transcription, DNA-templated
BP	IEA	GO:0016575	histone deacetylation
BP	IEA	GO:0035914	skeletal muscle cell differentiation

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Gene expression in normal tissue: SAP30

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SAP30

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-212165	Epigenetic regulation of gene expression
reactome	R-HSA-3214815	HDACs deacetylate histones
reactome	R-HSA-3247509	Chromatin modifying enzymes
reactome	R-HSA-427413	NoRC negatively regulates rRNA expression
reactome	R-HSA-4839726	Chromatin organization
reactome	R-HSA-5250941	Negative epigenetic regulation of rRNA expression

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD399	Selumetinib	2
iGMDRD353	PD0325901	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SAP30

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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