CACNA2D2

Summary: Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
calcium voltage-gated channel auxiliary subunit alpha2delta 2MIM:607082Ensembl:ENSG00000007402HGNC:HGNC:1400PA260123p21.31

GO terms in CACNA2D2


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0007528neuromuscular junction development
BPIEAGO:0034765regulation of ion transmembrane transport
BPIEAGO:0040014regulation of multicellular organism growth
BPIEAGO:0046622positive regulation of organ growth
BPIEAGO:0048747muscle fiber development
BPTASGO:0050796regulation of insulin secretion
BPIEAGO:0060024rhythmic synaptic transmission
BPIEAGO:0070588calcium ion transmembrane transport
CCTASGO:0005886plasma membrane
CCIEAGO:0005891voltage-gated calcium channel complex
MFTASGO:0005245voltage-gated calcium channel activity
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: CACNA2D2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CACNA2D2


DatabasePathway IDPathway Des.
pharmgkbPA152241951Celecoxib Pathway, Pharmacodynamics
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04260Cardiac muscle contraction - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa05410Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
kegghsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)
kegghsa05414Dilated cardiomyopathy (DCM) - Homo sapiens (human)
smpdbSMP00296Acebutolol Action Pathway
smpdbSMP00297Alprenolol Action Pathway
smpdbSMP00298Atenolol Action Pathway
smpdbSMP00299Betaxolol Action Pathway
smpdbSMP00300Bisoprolol Action Pathway
smpdbSMP00301Esmolol Action Pathway
smpdbSMP00302Metoprolol Action Pathway
smpdbSMP00303Nadolol Action Pathway
smpdbSMP00304Oxprenolol Action Pathway
smpdbSMP00305Penbutolol Action Pathway
smpdbSMP00306Pindolol Action Pathway
smpdbSMP00307Propranolol Action Pathway
smpdbSMP00323Quinidine Action Pathway
smpdbSMP00324Procainamide (Antiarrhythmic) Action Pathway
smpdbSMP00325Disopyramide Action Pathway
smpdbSMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00327Phenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00328Lidocaine (Antiarrhythmic) Action Pathway
smpdbSMP00329Mexiletine Action Pathway
smpdbSMP00330Tocainide Action Pathway
smpdbSMP00331Flecainide Action Pathway
smpdbSMP00332Ibutilide Action Pathway
smpdbSMP00359Diltiazem Action Pathway
smpdbSMP00366Nebivolol Action Pathway
smpdbSMP00367Carvedilol Action Pathway
smpdbSMP00368Labetalol Action Pathway
smpdbSMP00375Verapamil Action Pathway
smpdbSMP00376Amlodipine Action Pathway
smpdbSMP00377Felodipine Action Pathway
smpdbSMP00378Isradipine Action Pathway
smpdbSMP00379Nifedipine Action Pathway
smpdbSMP00380Nimodipine Action Pathway
smpdbSMP00381Nisoldipine Action Pathway
smpdbSMP00382Nitrendipine Action Pathway
smpdbSMP00392Benzocaine Action Pathway
smpdbSMP00393Bupivacaine Action Pathway
smpdbSMP00394Chloroprocaine Action Pathway
smpdbSMP00395Cocaine Action Pathway
smpdbSMP00396Dibucaine Action Pathway
smpdbSMP00397Levobupivacaine Action Pathway
smpdbSMP00398Lidocaine (Local Anaesthetic) Action Pathway
smpdbSMP00399Mepivacaine Action Pathway
smpdbSMP00400Oxybuprocaine Action Pathway
smpdbSMP00401Prilocaine Action Pathway
smpdbSMP00402Procaine Action Pathway
smpdbSMP00403Proparacaine Action Pathway
smpdbSMP00404Ropivacaine Action Pathway
smpdbSMP00405Codeine Action Pathway
smpdbSMP00406Morphine Action Pathway
smpdbSMP00407Heroin Action Pathway
smpdbSMP00408Methadone Action Pathway
smpdbSMP00409Oxycodone Action Pathway
smpdbSMP00410Hydromorphone Action Pathway
smpdbSMP00411Hydrocodone Action Pathway
smpdbSMP00412Oxymorphone Action Pathway
smpdbSMP00413Alfentanil Action Pathway
smpdbSMP00414Carfentanil Action Pathway
smpdbSMP00415Fentanyl Action Pathway
smpdbSMP00416Remifentanil Action Pathway
smpdbSMP00417Sufentanil Action Pathway
smpdbSMP00422Imipramine Action Pathway
smpdbSMP00423Desipramine Action Pathway
smpdbSMP00424Citalopram Action Pathway
smpdbSMP00425Escitalopram Action Pathway
smpdbSMP00426Fluoxetine Action Pathway
smpdbSMP00431Nicotine Action Pathway
smpdbSMP00453Nateglinide Action Pathway
smpdbSMP00454Repaglinide Action Pathway
smpdbSMP00460Glibenclamide Action Pathway
smpdbSMP00461Gliclazide Action Pathway
smpdbSMP00588Muscle/Heart Contraction
smpdbSMP00619Felodipine Metabolism Pathway
smpdbSMP00643Pancreas Function
smpdbSMP00657Bopindolol Action Pathway
smpdbSMP00658Carteolol Action Pathway
smpdbSMP00659Timolol Action Pathway
smpdbSMP00660Sotalol Action Pathway
smpdbSMP00661Epinephrine Action Pathway
smpdbSMP00662Dobutamine Action Pathway
smpdbSMP00663Isoprenaline Action Pathway
smpdbSMP00664Arbutamine Action Pathway
smpdbSMP00665Amiodarone Action Pathway
smpdbSMP00666Levobunolol Action Pathway
smpdbSMP00667Metipranolol Action Pathway
smpdbSMP00668Bevantolol Action Pathway
smpdbSMP00669Practolol Action Pathway
smpdbSMP00670Bupranolol Action Pathway
smpdbSMP00671Tramadol Action Action Pathway
smpdbSMP00672Propoxyphene Action Pathway
smpdbSMP00673Levorphanol Action Pathway
smpdbSMP00674Anileridine Action Pathway
smpdbSMP00675Diphenoxylate Action Pathway
smpdbSMP00676Dezocine Action Pathway
smpdbSMP00677Levomethadyl Acetate Action Action Pathway
smpdbSMP00678Methadyl Acetate Action Pathway
smpdbSMP006793-Methylthiofentanyl Action Pathway
smpdbSMP00680Dimethylthiambutene Action Pathway
smpdbSMP00681Ethylmorphine Action Pathway
smpdbSMP00683Levallorphan Action Pathway
smpdbSMP00684Buprenorphine Action Pathway
smpdbSMP00685Alvimopan Action Pathway
smpdbSMP00686Pentazocine Action Pathway
smpdbSMP00687Naltrexone Action Pathway
smpdbSMP00688Naloxone Action Pathway
smpdbSMP00689Dihydromorphine Action Pathway
smpdbSMP00690Ketobemidone Action Pathway
smpdbSMP00691Nalbuphine Action Pathway
wikipathwaysWP2118Arrhythmogenic Right Ventricular Cardiomyopathy
wikipathwaysWP382MAPK Signaling Pathway
reactomeR-HSA-112308Presynaptic depolarization and calcium channel opening
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-400042Adrenaline,noradrenaline inhibits insulin secretion
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-5576891Cardiac conduction
reactomeR-HSA-5576892Phase 0 - rapid depolarisation
reactomeR-HSA-5576893Phase 2 - plateau phase

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD399Selumetinib1
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CACNA2D2

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