CACNA2D2


Summary: Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014].

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HGNC ID
PHARMGKB ID
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GO terms in CACNA2D2


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0007528 neuromuscular junction development
BP IEA GO:0034765 regulation of ion transmembrane transport
BP IEA GO:0040014 regulation of multicellular organism growth
BP IEA GO:0046622 positive regulation of organ growth
BP IEA GO:0048747 muscle fiber development
BP TAS GO:0050796 regulation of insulin secretion
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Gene expression in normal tissue: CACNA2D2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CACNA2D2


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Database
Pathway ID
Pathway Des.
pharmgkb PA152241951 Celecoxib Pathway, Pharmacodynamics
kegg hsa04010 MAPK signaling pathway - Homo sapiens (human)
kegg hsa04260 Cardiac muscle contraction - Homo sapiens (human)
kegg hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegg hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
kegg hsa05410 Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD399 Selumetinib 1
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CACNA2D2

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Reference ID
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Cancer
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No matching records found

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