KIF5C


Summary: The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015].

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GO terms in KIF5C


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0003777 microtubule motor activity
MF TAS GO:0003777 microtubule motor activity
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
MF IBA GO:0008017 microtubule binding
MF IEA GO:0008017 microtubule binding
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Gene expression in normal tissue: KIF5C

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 3

Gene-drug pathway distribution

ERK MAPK signaling2

Pathways in KIF5C


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Database
Pathway ID
Pathway Des.
kegg hsa04144 Endocytosis - Homo sapiens (human)
kegg hsa04728 Dopaminergic synapse - Homo sapiens (human)
reactome R-HSA-264876 Insulin processing
reactome R-HSA-2980736 Peptide hormone metabolism
reactome R-HSA-392499 Metabolism of proteins
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD399 Selumetinib 1
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KIF5C

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Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
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No matching records found

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