KIF5C
Summary: The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| kinesin family member 5C | MIM:604593 | Ensembl:ENSG00000168280 | HGNC:HGNC:6325 | PA30109 | 2q23.1-q23.2 |
GO terms in KIF5C
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003777 | microtubule motor activity |
| MF | TAS | GO:0003777 | microtubule motor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0008017 | microtubule binding |
| MF | IEA | GO:0008017 | microtubule binding |
| MF | IBA | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed |
| MF | IBA | GO:0016887 | ATPase activity |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005871 | kinesin complex |
| CC | TAS | GO:0005871 | kinesin complex |
| CC | IBA | GO:0005874 | microtubule |
| CC | IEA | GO:0005874 | microtubule |
| CC | IEA | GO:0030425 | dendrite |
| CC | IEA | GO:0035253 | ciliary rootlet |
| CC | ISS | GO:0043025 | neuronal cell body |
| CC | ISS | GO:0044295 | axonal growth cone |
| CC | ISS | GO:0150034 | distal axon |
| BP | TAS | GO:0006996 | organelle organization |
| BP | IBA | GO:0007018 | microtubule-based movement |
| BP | IBA | GO:0007411 | axon guidance |
| BP | IEA | GO:0008045 | motor neuron axon guidance |
| BP | IBA | GO:0030705 | cytoskeleton-dependent intracellular transport |
| BP | IBA | GO:0048489 | synaptic vesicle transport |
| BP | ISS | GO:0051028 | mRNA transport |
| BP | IBA | GO:0098971 | anterograde dendritic transport of neurotransmitter receptor complex |
Gene expression in normal tissue: KIF5C
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KIF5C
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| reactome | R-HSA-264876 | Insulin processing |
| reactome | R-HSA-2980736 | Peptide hormone metabolism |
| reactome | R-HSA-392499 | Metabolism of proteins |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KIF5C
CLASSFICATION
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