KIF5C
Summary: The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:604593 Ensembl IDEnsembl:ENSG00000168280 HGNC IDHGNC:HGNC:6325 PHARMGKB IDPA30109 Map Location2q23.1-q23.2 |
GO terms in KIF5C
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0003777 | microtubule motor activity |
MF | TAS | GO:0003777 | microtubule motor activity |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0005524 | ATP binding |
MF | IBA | GO:0008017 | microtubule binding |
MF | IEA | GO:0008017 | microtubule binding |
Gene expression in normal tissue: KIF5C
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KIF5C
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Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
reactome | R-HSA-264876 | Insulin processing |
reactome | R-HSA-2980736 | Peptide hormone metabolism |
reactome | R-HSA-392499 | Metabolism of proteins |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in KIF5C
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |