MTMR7
Summary: This gene encodes a member of the myotubularin family of tyrosine/dual-specificity phosphatases. The encoded protein is characterized by four distinct domains that are conserved among all members of the myotubularin family: the glucosyltransferase, Rab-like GTPase activator and myotubularins domain, the Rac-induced recruitment domain, the protein tyrosine phosphatases and dual-specificity phosphatases domain and the suppressor of variegation 3-9, enhancer-of-zeste, and trithorax interaction domain. This protein dephosphorylates the target substrates phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Mar 2009].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603562 Ensembl IDEnsembl:ENSG00000003987 HGNC IDHGNC:HGNC:7454 PHARMGKB IDPA31257 Map Location8p22 | |||||
GO terms in MTMR7
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006470 | protein dephosphorylation |
| BP | TAS | GO:0006661 | phosphatidylinositol biosynthetic process |
| BP | IEA | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| BP | IEA | GO:0046855 | inositol phosphate dephosphorylation |
| BP | IEA | GO:0046856 | phosphatidylinositol dephosphorylation |
| CC | IDA | GO:0005737 | cytoplasm |
Gene expression in normal tissue: MTMR7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MTMR7
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483249 | Inositol phosphate metabolism |
| reactome | R-HSA-1483255 | PI Metabolism |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MTMR7
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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