Summary: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008].

receptor activity modifying protein 2MIM:605154Ensembl:ENSG00000131477HGNC:HGNC:9844PA3420317q21.2

GO terms in RAMP2

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0001605adrenomedullin receptor activity
MFIPIGO:0005515protein binding
MFIBAGO:0008565protein transporter activity
MFIDAGO:0008565protein transporter activity
MFIBAGO:0015026coreceptor activity
MFISSGO:0015026coreceptor activity
MFIGIGO:0097643amylin receptor activity
MFIPIGO:1990409adrenomedullin binding
BPIEAGO:0001666response to hypoxia
BPISSGO:0002040sprouting angiogenesis
BPIBAGO:0006816calcium ion transport
BPIDAGO:0006816calcium ion transport
BPIEAGO:0006886intracellular protein transport
BPIBAGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIPIGO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway
BPISSGO:0007507heart development
BPIEAGO:0007565female pregnancy
BPISSGO:0008217regulation of blood pressure
BPIEAGO:0008277regulation of G-protein coupled receptor protein signaling pathway
BPIDAGO:0010628positive regulation of gene expression
BPIBAGO:0015031protein transport
BPIDAGO:0015031protein transport
BPIBAGO:0031623receptor internalization
BPIDAGO:0031623receptor internalization
BPIEAGO:0032355response to estradiol
BPIEAGO:0032570response to progesterone
BPIBAGO:0032870cellular response to hormone stimulus
BPIEAGO:0032870cellular response to hormone stimulus
BPIDAGO:0034333adherens junction assembly
BPISSGO:0035924cellular response to vascular endothelial growth factor stimulus
BPIDAGO:0043116negative regulation of vascular permeability
BPISSGO:0045766positive regulation of angiogenesis
BPIDAGO:0070830bicellular tight junction assembly
BPISSGO:0070831basement membrane assembly
BPIBAGO:0072659protein localization to plasma membrane
BPIDAGO:0072659protein localization to plasma membrane
BPISSGO:0097084vascular smooth muscle cell development
BPIGIGO:0097647amylin receptor signaling pathway
BPIPIGO:1990410adrenomedullin receptor signaling pathway
BPIDAGO:2000352negative regulation of endothelial cell apoptotic process
BPIEAGO:2001214positive regulation of vasculogenesis
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCTASGO:0005905clathrin-coated pit
CCIBAGO:0009986cell surface
CCIDAGO:0009986cell surface
CCIBAGO:0043235receptor complex
CCIDAGO:0043235receptor complex
CCIDAGO:1903143adrenomedullin receptor complex
CCIDAGO:1903440amylin receptor complex

Gene expression in normal tissue: RAMP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RAMP2

DatabasePathway IDPathway Des.
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373080Class B/2 (Secretin family receptors)
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418555G alpha (s) signalling events
reactomeR-HSA-419812Calcitonin-like ligand receptors
reactomeR-HSA-500792GPCR ligand binding

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RAMP2