RAMP2
Summary: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:605154 Ensembl IDEnsembl:ENSG00000131477 HGNC IDHGNC:HGNC:9844 PHARMGKB IDPA34203 Map Location17q21.2 | |||||
GO terms in RAMP2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0001605 | adrenomedullin receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008565 | protein transporter activity |
| MF | IDA | GO:0008565 | protein transporter activity |
| MF | IBA | GO:0015026 | coreceptor activity |
| MF | ISS | GO:0015026 | coreceptor activity |
Gene expression in normal tissue: RAMP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RAMP2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373080 | Class B/2 (Secretin family receptors) |
| reactome | R-HSA-388396 | GPCR downstream signalling |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RAMP2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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