ARHGAP33
Summary: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Alternative splice variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Rho GTPase activating protein 33 | MIM:614902 | Ensembl:ENSG00000004777 | HGNC:HGNC:23085 | PA165393003 | 19q13.12 |
GO terms in ARHGAP33
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IEA | GO:0043197 | dendritic spine |
| BP | IBA | GO:0007264 | small GTPase mediated signal transduction |
| BP | IEA | GO:0009636 | response to toxic substance |
| BP | IEA | GO:0015031 | protein transport |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
| BP | IEA | GO:0061001 | regulation of dendritic spine morphogenesis |
| MF | IBA | GO:0005096 | GTPase activator activity |
| MF | TAS | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0035091 | phosphatidylinositol binding |
Gene expression in normal tissue: ARHGAP33
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARHGAP33
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
| wikipathways | WP481 | Insulin Signaling |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARHGAP33
CLASSFICATION
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