CCNB1
Summary: The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). The encoded protein is necessary for proper control of the G2/M transition phase of the cell cycle. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin B1 | MIM:123836 | Ensembl:ENSG00000134057 | HGNC:HGNC:1579 | PA95 | 5q13.2 |
GO terms in CCNB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex |
| CC | IDA | GO:0000922 | spindle pole |
| CC | IDA | GO:0000942 | condensed nuclear chromosome outer kinetochore |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005759 | mitochondrial matrix |
| CC | IDA | GO:0005759 | mitochondrial matrix |
| CC | IBA | GO:0005813 | centrosome |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0016020 | membrane |
| CC | IBA | GO:0097125 | cyclin B1-CDK1 complex |
| CC | IDA | GO:0097125 | cyclin B1-CDK1 complex |
| BP | IBA | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IBA | GO:0000278 | mitotic cell cycle |
| BP | IEA | GO:0001556 | oocyte maturation |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IEA | GO:0001933 | negative regulation of protein phosphorylation |
| BP | TAS | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| BP | IMP | GO:0007052 | mitotic spindle organization |
| BP | TAS | GO:0007077 | mitotic nuclear envelope disassembly |
| BP | IBA | GO:0007080 | mitotic metaphase plate congression |
| BP | IMP | GO:0007080 | mitotic metaphase plate congression |
| BP | IBA | GO:0007088 | regulation of mitotic nuclear division |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IBA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0009612 | response to mechanical stimulus |
| BP | IEA | GO:0010629 | negative regulation of gene expression |
| BP | IDA | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0031145 | anaphase-promoting complex-dependent catabolic process |
| BP | IEA | GO:0031442 | positive regulation of mRNA 3'-end processing |
| BP | IEA | GO:0033129 | positive regulation of histone phosphorylation |
| BP | IEA | GO:0042246 | tissue regeneration |
| BP | IEA | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IBA | GO:0045787 | positive regulation of cell cycle |
| BP | IMP | GO:0045931 | positive regulation of mitotic cell cycle |
| BP | IEA | GO:0046680 | response to DDT |
| BP | IEA | GO:0048146 | positive regulation of fibroblast proliferation |
| BP | IEA | GO:0048565 | digestive tract development |
| BP | IEA | GO:0051301 | cell division |
| BP | TAS | GO:0051726 | regulation of cell cycle |
| BP | IMP | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore |
| BP | IEA | GO:0055015 | ventricular cardiac muscle cell development |
| BP | IEA | GO:0060045 | positive regulation of cardiac muscle cell proliferation |
| BP | IEA | GO:0060623 | regulation of chromosome condensation |
| BP | IEA | GO:0065003 | protein-containing complex assembly |
| BP | IEA | GO:0071283 | cellular response to iron(III) ion |
| BP | IEA | GO:0071398 | cellular response to fatty acid |
| BP | IEA | GO:0071407 | cellular response to organic cyclic compound |
| BP | IEA | GO:0071456 | cellular response to hypoxia |
| BP | IMP | GO:0090266 | regulation of mitotic cell cycle spindle assembly checkpoint |
| BP | IDA | GO:1905448 | positive regulation of mitochondrial ATP synthesis coupled electron transport |
| BP | IEA | GO:2000775 | histone H3-S10 phosphorylation involved in chromosome condensation |
| MF | IBA | GO:0004672 | protein kinase activity |
| MF | TAS | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IPI | GO:0005113 | patched binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity |
| MF | IBA | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IBA | GO:0035173 | histone kinase activity |
| MF | IEA | GO:0035173 | histone kinase activity |
| MF | IPI | GO:0044389 | ubiquitin-like protein ligase binding |
| MF | IDA | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity |
Gene expression in normal tissue: CCNB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CCNB1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| pid | cmyb_pathway | C-MYB transcription factor network |
| pid | foxm1pathway | FOXM1 transcription factor network |
| pid | foxopathway | FoxO family signaling |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| pid | p53downstreampathway | Direct p53 effectors |
| pid | p73pathway | p73 transcription factor network |
| pid | plk1_pathway | PLK1 signaling events |
| netpath | Pathway_Hedgehog | Hedgehog |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP1859 | Mitotic G2-G2-M phases |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP2516 | ATM Signaling Pathway |
| wikipathways | WP45 | G1 to S cell cycle control |
| wikipathways | WP707 | DNA Damage Response |
| reactome | R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation |
| reactome | R-HSA-113510 | E2F mediated regulation of DNA replication |
| reactome | R-HSA-156711 | Polo-like kinase mediated events |
| reactome | R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B |
| reactome | R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins |
| reactome | R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase |
| reactome | R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins |
| reactome | R-HSA-176412 | Phosphorylation of the APC/C |
| reactome | R-HSA-176417 | Phosphorylation of Emi1 |
| reactome | R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2299718 | Condensation of Prophase Chromosomes |
| reactome | R-HSA-2465910 | MASTL Facilitates Mitotic Progression |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2514853 | Condensation of Prometaphase Chromosomes |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-2980766 | Nuclear Envelope Breakdown |
| reactome | R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 |
| reactome | R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-4419969 | Depolymerisation of the Nuclear Lamina |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-453276 | Regulation of mitotic cell cycle |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes |
| reactome | R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69473 | G2/M DNA damage checkpoint |
| reactome | R-HSA-69478 | G2/M DNA replication checkpoint |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex |
| reactome | R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| biocarta | akap95pathway | akap95 role in mitosis and chromosome dynamics |
| biocarta | cellcyclepathway | cyclins and cell cycle regulation |
| biocarta | efppathway | estrogen responsive protein efp controls cell cycle and breast tumors growth |
| biocarta | g2pathway | cell cycle: g2/m checkpoint |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| biocarta | mprpathway | how progesterone initiates the oocyte maturation |
| biocarta | plk3pathway | regulation of cell cycle progression by plk3 |
| biocarta | ptc1pathway | sonic hedgehog receptor ptc1 regulates cell cycle |
| biocarta | stathminpathway | stathmin and breast cancer resistance to antimicrotubule agents |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD718 | Pyrvinium pamoate | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CCNB1
CLASSFICATION
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