CCNB1

Summary: The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). The encoded protein is necessary for proper control of the G2/M transition phase of the cell cycle. [provided by RefSeq, Aug 2017].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecyclin B1
OMIM IDMIM:123836
Ensembl IDEnsembl:ENSG00000134057
HGNC IDHGNC:HGNC:1579
PHARMGKB IDPA95
Map Location5q13.2

GO terms in CCNB1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0000307 cyclin-dependent protein kinase holoenzyme complex
CC IDA GO:0000922 spindle pole
CC IDA GO:0000942 condensed nuclear chromosome outer kinetochore
CC IBA GO:0005634 nucleus
CC IDA GO:0005634 nucleus
CC TAS GO:0005654 nucleoplasm
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Gene expression in normal tissue: CCNB1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 9

Gene-drug pathway distribution

undefined2ERK MAPK signaling1

Pathways in CCNB1


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Database
Pathway ID
Pathway Des.
kegg hsa04068 FoxO signaling pathway - Homo sapiens (human)
kegg hsa04110 Cell cycle - Homo sapiens (human)
kegg hsa04114 Oocyte meiosis - Homo sapiens (human)
kegg hsa04115 p53 signaling pathway - Homo sapiens (human)
kegg hsa04218 Cellular senescence - Homo sapiens (human)
kegg hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD399 Selumetinib 3
iGMDRD718 Pyrvinium pamoate 3
iGMDRD889 Compound 7d-cis 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CCNB1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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