CTNND2
Summary: This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| catenin delta 2 | MIM:604275 | Ensembl:ENSG00000169862 | HGNC:HGNC:2516 | PA27017 | 5p15.2 |
GO terms in CTNND2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008013 | beta-catenin binding |
| MF | IBA | GO:0045296 | cadherin binding |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IBA | GO:0007043 | cell-cell junction assembly |
| BP | TAS | GO:0007155 | cell adhesion |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0009966 | regulation of signal transduction |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | IBA | GO:0050808 | synapse organization |
| BP | IMP | GO:0050808 | synapse organization |
| BP | IMP | GO:0060828 | regulation of canonical Wnt signaling pathway |
| BP | IBA | GO:0060997 | dendritic spine morphogenesis |
| BP | IMP | GO:0060997 | dendritic spine morphogenesis |
| BP | IBA | GO:0098609 | cell-cell adhesion |
| BP | IEA | GO:0098609 | cell-cell adhesion |
| CC | IBA | GO:0005634 | nucleus |
| CC | IEA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005911 | cell-cell junction |
| CC | IEA | GO:0005912 | adherens junction |
| CC | IBA | GO:0005913 | cell-cell adherens junction |
| CC | IBA | GO:0014069 | postsynaptic density |
| CC | IEA | GO:0030425 | dendrite |
| CC | IDA | GO:0043204 | perikaryon |
Gene expression in normal tissue: CTNND2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CTNND2
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