NHLH1


Summary: The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM, Nov 2002].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
nescient helix-loop-helix 1MIM:162360Ensembl:ENSG00000171786HGNC:HGNC:7817PA316191q23.2

GO terms in NHLH1


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005634nucleus
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0006366transcription by RNA polymerase II
BPTASGO:0007417central nervous system development
BPIEAGO:0030154cell differentiation
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
MFIBAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFIDAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFIBAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIEAGO:0046983protein dimerization activity

Gene expression in normal tissue: NHLH1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NHLH1


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD399Selumetinib1
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NHLH1

​​​​