IGF2BP2
Summary: This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:608289 Ensembl IDEnsembl:ENSG00000073792 HGNC IDHGNC:HGNC:28867 PHARMGKB IDPA128394577 Map Location3q27.2 | |||||
GO terms in IGF2BP2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0009653 | anatomical structure morphogenesis |
| BP | ISS | GO:0017148 | negative regulation of translation |
| BP | IC | GO:0042035 | regulation of cytokine biosynthetic process |
| BP | TAS | GO:0043488 | regulation of mRNA stability |
| BP | IEA | GO:0051028 | mRNA transport |
| CC | IDA | GO:0005634 | nucleus |
Gene expression in normal tissue: IGF2BP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IGF2BP2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA |
| reactome | R-HSA-8953854 | Metabolism of RNA |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IGF2BP2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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