DPYSL5


Summary: This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
dihydropyrimidinase like 5MIM:608383Ensembl:ENSG00000157851HGNC:HGNC:20637PA1349274132p23.3

GO terms in DPYSL5


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0007165signal transduction
BPTASGO:0007399nervous system development
BPIEAGO:0007411axon guidance
CCTASGO:0005829cytosol
CCIEAGO:0030425dendrite
CCIEAGO:0043025neuronal cell body
MFIPIGO:0005515protein binding
MFIEAGO:0008017microtubule binding
MFIEAGO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

Gene expression in normal tissue: DPYSL5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DPYSL5


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-373755Semaphorin interactions
reactomeR-HSA-399956CRMPs in Sema3A signaling
reactomeR-HSA-422475Axon guidance
kegghsa04360Axon guidance - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012
iGMDRD399Selumetinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DPYSL5

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