DPYSL5
Summary: This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dihydropyrimidinase like 5 | MIM:608383 | Ensembl:ENSG00000157851 | HGNC:HGNC:20637 | PA134927413 | 2p23.3 |
GO terms in DPYSL5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007399 | nervous system development |
| BP | IEA | GO:0007411 | axon guidance |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0030425 | dendrite |
| CC | IEA | GO:0043025 | neuronal cell body |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008017 | microtubule binding |
| MF | IEA | GO:0016810 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
Gene expression in normal tissue: DPYSL5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DPYSL5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-399956 | CRMPs in Sema3A signaling |
| reactome | R-HSA-422475 | Axon guidance |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DPYSL5
CLASSFICATION
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