CACNA1B
Summary: The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| calcium voltage-gated channel subunit alpha1 B | MIM:601012 | Ensembl:ENSG00000148408 | HGNC:HGNC:1389 | PA26008 | 9q34.3 |
GO terms in CACNA1B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005891 | voltage-gated calcium channel complex |
| CC | IEA | GO:0030425 | dendrite |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IEA | GO:0098793 | presynapse |
| BP | IBA | GO:0006816 | calcium ion transport |
| BP | IBA | GO:0007268 | chemical synaptic transmission |
| BP | TAS | GO:0007268 | chemical synaptic transmission |
| BP | IEA | GO:0007269 | neurotransmitter secretion |
| BP | IEA | GO:0007626 | locomotory behavior |
| BP | IEA | GO:0008016 | regulation of heart contraction |
| BP | IEA | GO:0008217 | regulation of blood pressure |
| BP | IEA | GO:0034765 | regulation of ion transmembrane transport |
| BP | IEA | GO:0048265 | response to pain |
| BP | TAS | GO:0051899 | membrane depolarization |
| BP | IEA | GO:0051924 | regulation of calcium ion transport |
| BP | IBA | GO:0070509 | calcium ion import |
| BP | IEA | GO:0070588 | calcium ion transmembrane transport |
| MF | IBA | GO:0005245 | voltage-gated calcium channel activity |
| MF | TAS | GO:0005245 | voltage-gated calcium channel activity |
| MF | TAS | GO:0005262 | calcium channel activity |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0008022 | protein C-terminus binding |
Gene expression in normal tissue: CACNA1B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CACNA1B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112308 | Presynaptic depolarization and calcium channel opening |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| wikipathways | WP2267 | Synaptic Vesicle Pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
| pharmgkb | PA152241951 | Celecoxib Pathway, Pharmacodynamics |
| pharmgkb | PA2024 | Beta-agonist/Beta-blocker Pathway, Pharmacodynamics |
| pharmgkb | PA2030 | Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction) |
| pharmgkb | PA2042 | Sympathetic Nerve Pathway (Neuroeffector Junction) |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04721 | Synaptic vesicle cycle - Homo sapiens (human) |
| kegg | hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| kegg | hsa04727 | GABAergic synapse - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04930 | Type II diabetes mellitus - Homo sapiens (human) |
| kegg | hsa05032 | Morphine addiction - Homo sapiens (human) |
| kegg | hsa05033 | Nicotine addiction - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CACNA1B
CLASSFICATION
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