Summary: The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].

calcium voltage-gated channel subunit alpha1 BMIM:601012Ensembl:ENSG00000148408HGNC:HGNC:1389PA260089q34.3

GO terms in CACNA1B

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005886plasma membrane
CCIEAGO:0005891voltage-gated calcium channel complex
CCIEAGO:0043025neuronal cell body
BPIBAGO:0006816calcium ion transport
BPIBAGO:0007268chemical synaptic transmission
BPTASGO:0007268chemical synaptic transmission
BPIEAGO:0007269neurotransmitter secretion
BPIEAGO:0007626locomotory behavior
BPIEAGO:0008016regulation of heart contraction
BPIEAGO:0008217regulation of blood pressure
BPIEAGO:0034765regulation of ion transmembrane transport
BPIEAGO:0048265response to pain
BPTASGO:0051899membrane depolarization
BPIEAGO:0051924regulation of calcium ion transport
BPIBAGO:0070509calcium ion import
BPIEAGO:0070588calcium ion transmembrane transport
MFIBAGO:0005245voltage-gated calcium channel activity
MFTASGO:0005245voltage-gated calcium channel activity
MFTASGO:0005262calcium channel activity
MFIEAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0008022protein C-terminus binding

Gene expression in normal tissue: CACNA1B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CACNA1B

DatabasePathway IDPathway Des.
reactomeR-HSA-112308Presynaptic depolarization and calcium channel opening
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
wikipathwaysWP2267Synaptic Vesicle Pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
pharmgkbPA152241951Celecoxib Pathway, Pharmacodynamics
pharmgkbPA2024Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
pharmgkbPA2030Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)
pharmgkbPA2042Sympathetic Nerve Pathway (Neuroeffector Junction)
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04721Synaptic vesicle cycle - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04726Serotonergic synapse - Homo sapiens (human)
kegghsa04727GABAergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04930Type II diabetes mellitus - Homo sapiens (human)
kegghsa05032Morphine addiction - Homo sapiens (human)
kegghsa05033Nicotine addiction - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CACNA1B