CACNA1B
Summary: The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:601012 Ensembl IDEnsembl:ENSG00000148408 HGNC IDHGNC:HGNC:1389 PHARMGKB IDPA26008 Map Location9q34.3 | |||||
GO terms in CACNA1B
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005891 | voltage-gated calcium channel complex |
| CC | IEA | GO:0030425 | dendrite |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IEA | GO:0098793 | presynapse |
| BP | IBA | GO:0006816 | calcium ion transport |
Gene expression in normal tissue: CACNA1B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CACNA1B
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112308 | Presynaptic depolarization and calcium channel opening |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| wikipathways | WP2267 | Synaptic Vesicle Pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CACNA1B
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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