TSPYL2
Summary: This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TSPY like 2 | MIM:300564 | Ensembl:ENSG00000184205 | HGNC:HGNC:24358 | PA134930188 | Xp11.22 |
GO terms in TSPYL2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0000182 | rDNA binding |
| MF | IPI | GO:0005515 | protein binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IEA | GO:0005737 | cytoplasm |
| BP | IEA | GO:0006334 | nucleosome assembly |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IDA | GO:0008156 | negative regulation of DNA replication |
| BP | NAS | GO:0009966 | regulation of signal transduction |
| BP | IDA | GO:0030308 | negative regulation of cell growth |
| BP | TAS | GO:0036498 | IRE1-mediated unfolded protein response |
| BP | NAS | GO:0045786 | negative regulation of cell cycle |
| BP | IDA | GO:0045859 | regulation of protein kinase activity |
Gene expression in normal tissue: TSPYL2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TSPYL2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-381038 | XBP1(S) activates chaperone genes |
| reactome | R-HSA-381070 | IRE1alpha activates chaperones |
| reactome | R-HSA-381119 | Unfolded Protein Response (UPR) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| wikipathways | WP3472 | XBP1(S) activates chaperone genes |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TSPYL2
CLASSFICATION
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