RGS20
Summary: The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| regulator of G protein signaling 20 | MIM:607193 | Ensembl:ENSG00000147509 | HGNC:HGNC:14600 | PA34373 | 8q11.23 |
GO terms in RGS20
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| BP | TAS | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway |
| BP | IEA | GO:0009968 | negative regulation of signal transduction |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| CC | IEA | GO:0005634 | nucleus |
| CC | IMP | GO:0005737 | cytoplasm |
| CC | IMP | GO:0005802 | trans-Golgi network |
Gene expression in normal tissue: RGS20
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RGS20
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-418597 | G alpha (z) signalling events |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RGS20
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