KCNN3


Summary: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
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GO terms in KCNN3


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0005516 calmodulin binding
MF IBA GO:0016286 small conductance calcium-activated potassium channel activity
CC IBA GO:0005886 plasma membrane
CC TAS GO:0005886 plasma membrane
CC IEA GO:0016021 integral component of membrane
CC IBA GO:0043005 neuron projection
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Gene expression in normal tissue: KCNN3

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

ERK MAPK signaling2

Pathways in KCNN3


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Database
Pathway ID
Pathway Des.
reactome R-HSA-112316 Neuronal System
reactome R-HSA-1296052 Ca2+ activated K+ channels
reactome R-HSA-1296071 Potassium Channels
kegg hsa04911 Insulin secretion - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
iGMDRD399 Selumetinib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNN3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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