Summary: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].

potassium calcium-activated channel subfamily N member 3MIM:602983Ensembl:ENSG00000143603HGNC:HGNC:6292PA300721q21.3

GO terms in KCNN3

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005516calmodulin binding
MFIBAGO:0016286small conductance calcium-activated potassium channel activity
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
CCIBAGO:0043005neuron projection
CCIBAGO:0043025neuronal cell body
BPIBAGO:0071805potassium ion transmembrane transport
BPIEAGO:0071805potassium ion transmembrane transport

Gene expression in normal tissue: KCNN3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNN3

DatabasePathway IDPathway Des.
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1296052Ca2+ activated K+ channels
reactomeR-HSA-1296071Potassium Channels
kegghsa04911Insulin secretion - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNN3