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CADPS

Summary: This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
calcium dependent secretion activator	MIM:604667	Ensembl:ENSG00000163618	HGNC:HGNC:1426	PA26024	3p14.2

GO terms in CADPS

Term Type	Evidence Type	GO Term ID	GO Des.
BP	TAS	GO:0006887	exocytosis
BP	IEA	GO:0015031	protein transport
BP	IEA	GO:0016050	vesicle organization
BP	IEA	GO:0016082	synaptic vesicle priming
BP	IEA	GO:0050432	catecholamine secretion
BP	IEA	GO:0099525	presynaptic dense core vesicle exocytosis
CC	TAS	GO:0005829	cytosol
CC	IEA	GO:0030054	cell junction
CC	IEA	GO:0030659	cytoplasmic vesicle membrane
CC	IEA	GO:0098793	presynapse
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0008289	lipid binding
MF	ISS	GO:0019901	protein kinase binding
MF	IEA	GO:0046872	metal ion binding

Gene expression in normal tissue: CADPS

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CADPS

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD399	Selumetinib	1
iGMDRD309	17AAG	1
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CADPS

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DATATYPES

CLASSFICATION

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