LDB2
Summary: The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603450 Ensembl IDEnsembl:ENSG00000169744 HGNC IDHGNC:HGNC:6533 PHARMGKB IDPA30317 Map Location4p15.32 | |||||
GO terms in LDB2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000989 | transcription factor activity, transcription factor binding |
| MF | IEA | GO:0000989 | transcription factor activity, transcription factor binding |
| MF | IBA | GO:0001102 | RNA polymerase II activating transcription factor binding |
| MF | TAS | GO:0003712 | transcription coregulator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0019899 | enzyme binding |
Gene expression in normal tissue: LDB2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LDB2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2858 | Ectoderm Differentiation |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD399 | Selumetinib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LDB2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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