UHMK1
Summary: The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| U2AF homology motif kinase 1 | MIM:608849 | Ensembl:ENSG00000152332 | HGNC:HGNC:19683 | PA134974001 | 1q23.3 |
GO terms in UHMK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0007050 | cell cycle arrest |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | ISS | GO:0018105 | peptidyl-serine phosphorylation |
| BP | ISS | GO:0031175 | neuron projection development |
| BP | ISS | GO:0045948 | positive regulation of translational initiation |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IBA | GO:0046825 | regulation of protein export from nucleus |
| BP | IDA | GO:0046825 | regulation of protein export from nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | ISS | GO:0030424 | axon |
| CC | ISS | GO:0032839 | dendrite cytoplasm |
| CC | IBA | GO:0035770 | ribonucleoprotein granule |
| CC | ISS | GO:0071598 | neuronal ribonucleoprotein granule |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IC | GO:0005524 | ATP binding |
| MF | IC | GO:0016740 | transferase activity |
| MF | IBA | GO:0043021 | ribonucleoprotein complex binding |
| MF | ISS | GO:0043021 | ribonucleoprotein complex binding |
Gene expression in normal tissue: UHMK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UHMK1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD870 | BRD63610 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UHMK1
CLASSFICATION
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