UHMK1


Summary: The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in UHMK1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IMP GO:0007050 cell cycle arrest
BP IBA GO:0018105 peptidyl-serine phosphorylation
BP IDA GO:0018105 peptidyl-serine phosphorylation
BP ISS GO:0018105 peptidyl-serine phosphorylation
BP ISS GO:0031175 neuron projection development
BP ISS GO:0045948 positive regulation of translational initiation
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Gene expression in normal tissue: UHMK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in UHMK1


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD399 Selumetinib 3
iGMDRD188 Piperlongumine 2
iGMDRD871 BRD6368 2
iGMDRD577 BIX01294 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in UHMK1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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