UHMK1


Summary: The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
U2AF homology motif kinase 1MIM:608849Ensembl:ENSG00000152332HGNC:HGNC:19683PA1349740011q23.3

GO terms in UHMK1


Term TypeEvidence TypeGO Term IDGO Des.
BPIMPGO:0007050cell cycle arrest
BPIBAGO:0018105peptidyl-serine phosphorylation
BPIDAGO:0018105peptidyl-serine phosphorylation
BPISSGO:0018105peptidyl-serine phosphorylation
BPISSGO:0031175neuron projection development
BPISSGO:0045948positive regulation of translational initiation
BPIDAGO:0046777protein autophosphorylation
BPIBAGO:0046825regulation of protein export from nucleus
BPIDAGO:0046825regulation of protein export from nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005794Golgi apparatus
CCISSGO:0030424axon
CCISSGO:0032839dendrite cytoplasm
CCIBAGO:0035770ribonucleoprotein granule
CCISSGO:0071598neuronal ribonucleoprotein granule
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFICGO:0005524ATP binding
MFICGO:0016740transferase activity
MFIBAGO:0043021ribonucleoprotein complex binding
MFISSGO:0043021ribonucleoprotein complex binding

Gene expression in normal tissue: UHMK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in UHMK1


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD399Selumetinib3
iGMDRD188Piperlongumine2
iGMDRD871BRD63682
iGMDRD577BIX012942
iGMDRD280CYTOCHALASIN B1
iGMDRD394BX-7953
iGMDRD434BMS-5369243
iGMDRD870BRD636102

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in UHMK1

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