Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017].

glutamate metabotropic receptor 2MIM:604099Ensembl:ENSG00000164082HGNC:HGNC:4594PA289913p21.2

GO terms in GRM2

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIEAGO:0030054cell junction
CCIEAGO:0042734presynaptic membrane
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007194negative regulation of adenylate cyclase activity
BPIEAGO:0007196adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
BPIBAGO:0007216G-protein coupled glutamate receptor signaling pathway
BPTASGO:0007268chemical synaptic transmission
BPIEAGO:0014047glutamate secretion
BPIBAGO:0051966regulation of synaptic transmission, glutamatergic
MFIEAGO:0001641group II metabotropic glutamate receptor activity
MFTASGO:0004930G-protein coupled receptor activity
MFIBAGO:0005246calcium channel regulator activity
MFIPIGO:0005515protein binding
MFIBAGO:0008066glutamate receptor activity
MFTASGO:0008066glutamate receptor activity

Gene expression in normal tissue: GRM2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GRM2

DatabasePathway IDPathway Des.
wikipathwaysWP501GPCRs, Class C Metabotropic glutamate, pheromone
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)
kegghsa05030Cocaine addiction - Homo sapiens (human)
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-420499Class C/3 (Metabotropic glutamate/pheromone receptors)
reactomeR-HSA-500792GPCR ligand binding

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GRM2