FYB1

Summary: The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameFYN binding protein 1
OMIM IDMIM:602731
Ensembl IDEnsembl:ENSG00000082074
HGNC IDHGNC:HGNC:4036
PHARMGKB IDPA28452
Map Location5p13.1

GO terms in FYB1


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0005102 signaling receptor binding
MF IPI GO:0005515 protein binding
MF IEA GO:0008289 lipid binding
MF IEA GO:0044877 protein-containing complex binding
BP TAS GO:0006468 protein phosphorylation
BP TAS GO:0006607 NLS-bearing protein import into nucleus
Showing 1 to 6 of 18 rows rows per page

Gene expression in normal tissue: FYB1

Gene-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

ERK MAPK signaling2

Pathways in FYB1


Loading, please wait...
Database
Pathway ID
Pathway Des.
wikipathways WP69 T-Cell antigen Receptor (TCR) Signaling Pathway
pid tcr_pathway TCR signaling in naïve CD4+ T cells
netpath Pathway_TCR TCR
kegg hsa04015 Rap1 signaling pathway - Homo sapiens (human)
reactome R-HSA-1280218 Adaptive Immune System
reactome R-HSA-1280218 Adaptive Immune System
Showing 1 to 6 of 14 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
iGMDRD399 Selumetinib 2
Showing 1 to 2 of 2 rows

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FYB1

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.