LIPH

Summary: This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namelipase H
OMIM IDMIM:607365
Ensembl IDEnsembl:ENSG00000163898
HGNC IDHGNC:HGNC:18483
PHARMGKB IDPA134934352
Map Location3q27.2

GO terms in LIPH


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0004620 phospholipase activity
MF TAS GO:0004620 phospholipase activity
MF IDA GO:0008201 heparin binding
MF IEA GO:0052689 carboxylic ester hydrolase activity
CC IDA GO:0005615 extracellular space
CC IDA GO:0005886 plasma membrane
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Gene expression in normal tissue: LIPH

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LIPH


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1430728 Metabolism
reactome R-HSA-1483166 Synthesis of PA
reactome R-HSA-1483206 Glycerophospholipid biosynthesis
reactome R-HSA-1483257 Phospholipid metabolism
reactome R-HSA-556833 Metabolism of lipids
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
iGMDRD399 Selumetinib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LIPH

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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