ERO1A
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| endoplasmic reticulum oxidoreductase 1 alpha | MIM:615435 | Ensembl:ENSG00000197930 | HGNC:HGNC:13280 | PA27862 | 14q22.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in ERO1A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003756 | protein disulfide isomerase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0015035 | protein disulfide oxidoreductase activity |
| MF | TAS | GO:0015036 | disulfide oxidoreductase activity |
| MF | IDA | GO:0016491 | oxidoreductase activity |
| MF | IEA | GO:0016671 | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | IBA | GO:0005789 | endoplasmic reticulum membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0030425 | dendrite |
| CC | TAS | GO:0043231 | intracellular membrane-bounded organelle |
| BP | TAS | GO:0006457 | protein folding |
| BP | TAS | GO:0006464 | cellular protein modification process |
| BP | TAS | GO:0009266 | response to temperature stimulus |
| BP | IEA | GO:0010260 | animal organ senescence |
| BP | IEA | GO:0019471 | 4-hydroxyproline metabolic process |
| BP | IEA | GO:0022417 | protein maturation by protein folding |
| BP | IEA | GO:0030198 | extracellular matrix organization |
| BP | IEA | GO:0030968 | endoplasmic reticulum unfolded protein response |
| BP | TAS | GO:0034599 | cellular response to oxidative stress |
| BP | IBA | GO:0034975 | protein folding in endoplasmic reticulum |
| BP | ISS | GO:0034976 | response to endoplasmic reticulum stress |
| BP | IEA | GO:0045454 | cell redox homeostasis |
| BP | IEA | GO:0050873 | brown fat cell differentiation |
| BP | IDA | GO:0051085 | chaperone cofactor-dependent protein refolding |
| BP | ISS | GO:0051209 | release of sequestered calcium ion into cytosol |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | ISS | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| BP | IEA | GO:0071456 | cellular response to hypoxia |
Gene expression in normal tissue: ERO1A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ERO1A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| kegg | hsa05110 | Vibrio cholerae infection - Homo sapiens (human) |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-264876 | Insulin processing |
| reactome | R-HSA-2980736 | Peptide hormone metabolism |
| reactome | R-HSA-3299685 | Detoxification of Reactive Oxygen Species |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ERO1A
CLASSFICATION
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