SLC35D2

Summary: Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]).[supplied by OMIM, Mar 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namesolute carrier family 35 member D2
OMIM IDMIM:609182
Ensembl IDEnsembl:ENSG00000285269
HGNC IDHGNC:HGNC:20799
PHARMGKB IDPA134909604
Map Location9q22.32

Gene Categories:

TRANSPORTER

GO terms in SLC35D2


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0006024 glycosaminoglycan biosynthetic process
BP ND GO:0008150 biological_process
BP IEA GO:0008643 carbohydrate transport
BP TAS GO:0018146 keratan sulfate biosynthetic process
BP IEA GO:0090481 pyrimidine nucleotide-sugar transmembrane transport
CC TAS GO:0000139 Golgi membrane
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Gene expression in normal tissue: SLC35D2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 3

Gene-drug pathway distribution

ERK MAPK signaling2

Pathways in SLC35D2


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1430728 Metabolism
reactome R-HSA-1630316 Glycosaminoglycan metabolism
reactome R-HSA-1638074 Keratan sulfate/keratin metabolism
reactome R-HSA-1638091 Heparan sulfate/heparin (HS-GAG) metabolism
reactome R-HSA-2022854 Keratan sulfate biosynthesis
reactome R-HSA-2022928 HS-GAG biosynthesis
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD399 Selumetinib 1
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SLC35D2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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