SLC35D2
Summary: Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier family 35 member D2 | MIM:609182 | Ensembl:ENSG00000285269 | HGNC:HGNC:20799 | PA134909604 | 9q22.32 |
Gene Categories:
TRANSPORTERGO terms in SLC35D2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006024 | glycosaminoglycan biosynthetic process |
| BP | ND | GO:0008150 | biological_process |
| BP | IEA | GO:0008643 | carbohydrate transport |
| BP | TAS | GO:0018146 | keratan sulfate biosynthetic process |
| BP | IEA | GO:0090481 | pyrimidine nucleotide-sugar transmembrane transport |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | ND | GO:0005575 | cellular_component |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IEA | GO:0016021 | integral component of membrane |
| MF | NAS | GO:0005338 | nucleotide-sugar transmembrane transporter activity |
| MF | TAS | GO:0005338 | nucleotide-sugar transmembrane transporter activity |
| MF | IBA | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity |
Gene expression in normal tissue: SLC35D2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC35D2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1630316 | Glycosaminoglycan metabolism |
| reactome | R-HSA-1638074 | Keratan sulfate/keratin metabolism |
| reactome | R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism |
| reactome | R-HSA-2022854 | Keratan sulfate biosynthesis |
| reactome | R-HSA-2022928 | HS-GAG biosynthesis |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
| reactome | R-HSA-727802 | Transport of nucleotide sugars |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC35D2
CLASSFICATION
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