SSTR2
Summary: Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| somatostatin receptor 2 | MIM:182452 | Ensembl:ENSG00000180616 | HGNC:HGNC:11331 | PA36155 | 17q25.1 |
GO terms in SSTR2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006937 | regulation of muscle contraction |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IBA | GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| BP | TAS | GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| BP | IEA | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway |
| BP | IBA | GO:0007218 | neuropeptide signaling pathway |
| BP | IEA | GO:0007218 | neuropeptide signaling pathway |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0021549 | cerebellum development |
| BP | IEA | GO:0030432 | peristalsis |
| BP | IEA | GO:0030900 | forebrain development |
| BP | IEA | GO:0038170 | somatostatin signaling pathway |
| BP | IEA | GO:0042594 | response to starvation |
| BP | IBA | GO:0071385 | cellular response to glucocorticoid stimulus |
| BP | IBA | GO:0071392 | cellular response to estradiol stimulus |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0043005 | neuron projection |
| MF | IBA | GO:0004930 | G-protein coupled receptor activity |
| MF | IBA | GO:0004994 | somatostatin receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0030165 | PDZ domain binding |
| MF | IBA | GO:0042277 | peptide binding |
| MF | IBA | GO:0042923 | neuropeptide binding |
Gene expression in normal tissue: SSTR2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SSTR2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA152530845 | Proton Pump Inhibitor Pathway, Pharmacodynamics |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04971 | Gastric acid secretion - Homo sapiens (human) |
| wikipathways | WP117 | GPCRs, Other |
| wikipathways | WP24 | Peptide GPCRs |
| wikipathways | WP455 | GPCRs, Class A Rhodopsin-like |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-375276 | Peptide ligand-binding receptors |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-500792 | GPCR ligand binding |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SSTR2
CLASSFICATION
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