SSTR2

Summary: Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namesomatostatin receptor 2
OMIM IDMIM:182452
Ensembl IDEnsembl:ENSG00000180616
HGNC IDHGNC:HGNC:11331
PHARMGKB IDPA36155
Map Location17q25.1

GO terms in SSTR2


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0006937 regulation of muscle contraction
BP TAS GO:0007186 G-protein coupled receptor signaling pathway
BP IBA GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
BP TAS GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
BP IEA GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
BP IBA GO:0007218 neuropeptide signaling pathway
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Gene expression in normal tissue: SSTR2

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 3

Gene-drug pathway distribution

ERK MAPK signaling2

Pathways in SSTR2


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Database
Pathway ID
Pathway Des.
pharmgkb PA152530845 Proton Pump Inhibitor Pathway, Pharmacodynamics
kegg hsa04024 cAMP signaling pathway - Homo sapiens (human)
kegg hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegg hsa04971 Gastric acid secretion - Homo sapiens (human)
wikipathways WP117 GPCRs, Other
wikipathways WP24 Peptide GPCRs
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD399 Selumetinib 1
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SSTR2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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