TIGIT


Summary: This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
T cell immunoreceptor with Ig and ITIM domainsMIM:612859Ensembl:ENSG00000181847HGNC:HGNC:26838PA1647264823q13.31

Gene Categories:

CELL SURFACE

GO terms in TIGIT


Term TypeEvidence TypeGO Term IDGO Des.
BPIMPGO:0032695negative regulation of interleukin-12 production
BPIMPGO:0032733positive regulation of interleukin-10 production
BPIDAGO:0050868negative regulation of T cell activation
BPIMPGO:0050868negative regulation of T cell activation
CCIDAGO:0009986cell surface
MFIPIGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding

Gene expression in normal tissue: TIGIT

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TIGIT


DatabasePathway IDPathway Des.
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD399Selumetinib1
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TIGIT

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