TIGIT
Summary: This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:612859 Ensembl IDEnsembl:ENSG00000181847 HGNC IDHGNC:HGNC:26838 PHARMGKB IDPA164726482 Map Location3q13.31 | |||||
Gene Categories:
CELL SURFACEGO terms in TIGIT
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0032695 | negative regulation of interleukin-12 production |
| BP | IMP | GO:0032733 | positive regulation of interleukin-10 production |
| BP | IDA | GO:0050868 | negative regulation of T cell activation |
| BP | IMP | GO:0050868 | negative regulation of T cell activation |
| CC | IDA | GO:0009986 | cell surface |
| MF | IPI | GO:0005102 | signaling receptor binding |
Gene expression in normal tissue: TIGIT
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TIGIT
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TIGIT
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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