PCLO
Summary: The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:604918 Ensembl IDEnsembl:ENSG00000186472 HGNC IDHGNC:HGNC:13406 PHARMGKB IDPA33072 Map Location7q21.11 | |||||
GO terms in PCLO
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | NAS | GO:0005856 | cytoskeleton |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | IEA | GO:0030054 | cell junction |
| CC | ISS | GO:0045202 | synapse |
| CC | TAS | GO:0048788 | cytoskeleton of presynaptic active zone |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: PCLO
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PCLO
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PCLO
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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