PCLO
Summary: The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| piccolo presynaptic cytomatrix protein | MIM:604918 | Ensembl:ENSG00000186472 | HGNC:HGNC:13406 | PA33072 | 7q21.11 |
GO terms in PCLO
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | NAS | GO:0005856 | cytoskeleton |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | IEA | GO:0030054 | cell junction |
| CC | ISS | GO:0045202 | synapse |
| CC | TAS | GO:0048788 | cytoskeleton of presynaptic active zone |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | ISS | GO:0007010 | cytoskeleton organization |
| BP | IEA | GO:0007416 | synapse assembly |
| BP | NAS | GO:0016079 | synaptic vesicle exocytosis |
| BP | IEA | GO:0017157 | regulation of exocytosis |
| BP | IEA | GO:0019933 | cAMP-mediated signaling |
| BP | IEA | GO:0030073 | insulin secretion |
| BP | IEA | GO:0035418 | protein localization to synapse |
| BP | IEA | GO:0099526 | presynapse to nucleus signaling pathway |
| MF | ISS | GO:0005509 | calcium ion binding |
| MF | ISS | GO:0005522 | profilin binding |
| MF | ISS | GO:0005544 | calcium-dependent phospholipid binding |
Gene expression in normal tissue: PCLO
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 2 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD399 | Selumetinib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PCLO
CLASSFICATION
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