KDM2B
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| lysine demethylase 2B | MIM:609078 | Ensembl:ENSG00000089094 | HGNC:HGNC:13610 | PA164721242 | 12q24.31 |
Gene Categories:
HISTONE MODIFICATIONGO terms in KDM2B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | NAS | GO:0003677 | DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0019843 | rRNA binding |
| MF | TAS | GO:0032452 | histone demethylase activity |
| MF | IEA | GO:0051864 | histone demethylase activity (H3-K36 specific) |
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | ISS | GO:0007283 | spermatogenesis |
| BP | ISS | GO:0021555 | midbrain-hindbrain boundary morphogenesis |
| BP | ISS | GO:0021592 | fourth ventricle development |
| BP | ISS | GO:0021670 | lateral ventricle development |
| BP | ISS | GO:0021678 | third ventricle development |
| BP | ISS | GO:0021993 | initiation of neural tube closure |
| BP | IEA | GO:0030307 | positive regulation of cell growth |
| BP | ISS | GO:0030900 | forebrain development |
| BP | ISS | GO:0030901 | midbrain development |
| BP | ISS | GO:0030902 | hindbrain development |
| BP | IDA | GO:0035518 | histone H2A monoubiquitination |
| BP | ISS | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | ISS | GO:0048596 | embryonic camera-type eye morphogenesis |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | IEA | GO:0070544 | histone H3-K36 demethylation |
| BP | IEA | GO:1902459 | positive regulation of stem cell population maintenance |
| BP | ISS | GO:2000178 | negative regulation of neural precursor cell proliferation |
| CC | NAS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005730 | nucleolus |
| CC | IDA | GO:0031519 | PcG protein complex |
Gene expression in normal tissue: KDM2B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KDM2B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-3214842 | HDMs demethylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KDM2B
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