KCNB2


Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008].

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GO terms in KCNB2


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Term Type
Evidence Type
GO Term ID
GO Des.
BP ISS GO:0006813 potassium ion transport
BP TAS GO:0006940 regulation of smooth muscle contraction
BP IEA GO:0034765 regulation of ion transmembrane transport
BP IEA GO:0051260 protein homooligomerization
BP IBA GO:0071805 potassium ion transmembrane transport
BP ISS GO:0071805 potassium ion transmembrane transport
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Gene expression in normal tissue: KCNB2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNB2


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Database
Pathway ID
Pathway Des.
reactome R-HSA-112316 Neuronal System
reactome R-HSA-1296071 Potassium Channels
reactome R-HSA-1296072 Voltage gated Potassium channels
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
iGMDRD309 17AAG 1
iGMDRD399 Selumetinib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNB2

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Level
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Cancer
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No matching records found

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