SEARCH

HOME / SEARCH / SEZ6

SEZ6

Summary: The protein encoded by this gene is thought to contain five cysteine-rich motifs that are similar to sushi domains, as well as two domains similar to the amino terminal half of the CUB (for complement C1r/C1s, Uegf, Bmp1) domain. Mutations in this gene have been associated with febrile seizures. [provided by RefSeq, Jul 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
seizure related 6 homolog	MIM:616666	Ensembl:ENSG00000063015	HGNC:HGNC:15955	PA38065	17q11.2

GO terms in SEZ6

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0008344	adult locomotory behavior
BP	IEA	GO:0021680	cerebellar Purkinje cell layer development
BP	IEA	GO:0060074	synapse maturation
BP	IEA	GO:0060079	excitatory postsynaptic potential
BP	IEA	GO:0090036	regulation of protein kinase C signaling
BP	IEA	GO:1900006	positive regulation of dendrite development
BP	IEA	GO:2000171	negative regulation of dendrite development
CC	IEA	GO:0005615	extracellular space
CC	IEA	GO:0005783	endoplasmic reticulum
CC	IEA	GO:0005886	plasma membrane
CC	IEA	GO:0016021	integral component of membrane
CC	IEA	GO:0043025	neuronal cell body
CC	IEA	GO:0043197	dendritic spine
CC	IEA	GO:0043198	dendritic shaft
CC	IEA	GO:0048471	perinuclear region of cytoplasm
CC	IEA	GO:0097440	apical dendrite

Gene expression in normal tissue: SEZ6

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SEZ6

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD399	Selumetinib	1
iGMDRD353	PD0325901	1
iGMDRD309	17AAG	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SEZ6

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.