RPS2
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ribosomal protein S2 | MIM:603624 | Ensembl:ENSG00000140988 | HGNC:HGNC:10404 | PA34806 | 16p13.3 |
GO terms in RPS2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003729 | mRNA binding |
| MF | HDA | GO:0003735 | structural constituent of ribosome |
| MF | IBA | GO:0003735 | structural constituent of ribosome |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0017134 | fibroblast growth factor binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | HDA | GO:0045296 | cadherin binding |
| BP | TAS | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| BP | TAS | GO:0006364 | rRNA processing |
| BP | IC | GO:0006412 | translation |
| BP | TAS | GO:0006413 | translational initiation |
| BP | TAS | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane |
| BP | IDA | GO:0051443 | positive regulation of ubiquitin-protein transferase activity |
| CC | HDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | HDA | GO:0016020 | membrane |
| CC | HDA | GO:0022627 | cytosolic small ribosomal subunit |
| CC | IBA | GO:0022627 | cytosolic small ribosomal subunit |
| CC | IDA | GO:0022627 | cytosolic small ribosomal subunit |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: RPS2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPS2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP477 | Cytoplasmic Ribosomal Proteins |
| kegg | hsa03010 | Ribosome - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression |
| reactome | R-HSA-156842 | Eukaryotic Translation Elongation |
| reactome | R-HSA-156902 | Peptide chain elongation |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168254 | Influenza Infection |
| reactome | R-HSA-168255 | Influenza Life Cycle |
| reactome | R-HSA-168273 | Influenza Viral RNA Transcription and Replication |
| reactome | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane |
| reactome | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane |
| reactome | R-HSA-192823 | Viral mRNA Translation |
| reactome | R-HSA-2408522 | Selenoamino acid metabolism |
| reactome | R-HSA-2408557 | Selenocysteine synthesis |
| reactome | R-HSA-3214858 | RMTs methylate histone arginines |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6790901 | rRNA modification in the nucleus and cytosol |
| reactome | R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol |
| reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
| reactome | R-HSA-72312 | rRNA processing |
| reactome | R-HSA-72312 | rRNA processing |
| reactome | R-HSA-72613 | Eukaryotic Translation Initiation |
| reactome | R-HSA-72649 | Translation initiation complex formation |
| reactome | R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| reactome | R-HSA-72689 | Formation of a pool of free 40S subunits |
| reactome | R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex |
| reactome | R-HSA-72702 | Ribosomal scanning and start codon recognition |
| reactome | R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| reactome | R-HSA-72737 | Cap-dependent Translation Initiation |
| reactome | R-HSA-72764 | Eukaryotic Translation Termination |
| reactome | R-HSA-72766 | Translation |
| reactome | R-HSA-72766 | Translation |
| reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
| reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
| reactome | R-HSA-8876725 | Protein methylation |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-9010553 | Regulation of expression of SLITs and ROBOs |
| reactome | R-HSA-927802 | Nonsense-Mediated Decay (NMD) |
| reactome | R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| reactome | R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RPS2
CLASSFICATION
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