PLCH2
Summary: PLCH2 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol (Zhou et al., 2005 [PubMed 16107206]).[supplied by OMIM, Jun 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phospholipase C eta 2 | MIM:612836 | Ensembl:ENSG00000149527 | HGNC:HGNC:29037 | PA134914471 | 1p36.32 |
GO terms in PLCH2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ND | GO:0008150 | biological_process |
| BP | IEA | GO:0016042 | lipid catabolic process |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0043647 | inositol phosphate metabolic process |
| BP | IEA | GO:0046488 | phosphatidylinositol metabolic process |
| CC | ND | GO:0005575 | cellular_component |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005886 | plasma membrane |
| MF | ND | GO:0003674 | molecular_function |
| MF | TAS | GO:0004435 | phosphatidylinositol phospholipase C activity |
| MF | IEA | GO:0005509 | calcium ion binding |
Gene expression in normal tissue: PLCH2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLCH2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483249 | Inositol phosphate metabolism |
| reactome | R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol |
| humancyc | LIPASYN-PWY | phospholipases |
| humancyc | PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
| humancyc | PWY-6367 | D-myo-inositol-5-phosphate metabolism |
| humancyc | PWY-6371 | superpathway of inositol phosphate compounds |
| pharmgkb | PA152530845 | Proton Pump Inhibitor Pathway, Pharmacodynamics |
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLCH2
CLASSFICATION
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