PLCH2
Summary: PLCH2 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol (Zhou et al., 2005 [PubMed 16107206]).[supplied by OMIM, Jun 2009].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:612836 Ensembl IDEnsembl:ENSG00000149527 HGNC IDHGNC:HGNC:29037 PHARMGKB IDPA134914471 Map Location1p36.32 | |||||
GO terms in PLCH2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ND | GO:0008150 | biological_process |
| BP | IEA | GO:0016042 | lipid catabolic process |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0043647 | inositol phosphate metabolic process |
| BP | IEA | GO:0046488 | phosphatidylinositol metabolic process |
| CC | ND | GO:0005575 | cellular_component |
Gene expression in normal tissue: PLCH2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLCH2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483249 | Inositol phosphate metabolism |
| reactome | R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol |
| humancyc | LIPASYN-PWY | phospholipases |
| humancyc | PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
| humancyc | PWY-6367 | D-myo-inositol-5-phosphate metabolism |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD399 | Selumetinib | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLCH2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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