PKM


Summary: This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
pyruvate kinase M1/2MIM:179050Ensembl:ENSG00000067225HGNC:HGNC:9021PA3335315q23

Gene Categories:

DRUGGABLE GENOMEKINASE

GO terms in PKM


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000287magnesium ion binding
MFHDAGO:0003723RNA binding
MFEXPGO:0004743pyruvate kinase activity
MFIBAGO:0004743pyruvate kinase activity
MFIDAGO:0004743pyruvate kinase activity
MFTASGO:0004743pyruvate kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0016301kinase activity
MFHDAGO:0023026MHC class II protein complex binding
MFIEAGO:0030955potassium ion binding
MFIEAGO:0042802identical protein binding
MFIEAGO:0043531ADP binding
MFHDAGO:0045296cadherin binding
MFIEAGO:0070324thyroid hormone binding
CCIEAGO:0001917photoreceptor inner segment
CCTASGO:0005576extracellular region
CCHDAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCHDAGO:0005739mitochondrion
CCIDAGO:0005829cytosol
CCNASGO:0005829cytosol
CCTASGO:0005829cytosol
CCIEAGO:0005929cilium
CCHDAGO:0031012extracellular matrix
CCHDAGO:0031982vesicle
CCTASGO:0034774secretory granule lumen
CCIEAGO:0043209myelin sheath
CCHDAGO:0070062extracellular exosome
CCIEAGO:1902912pyruvate kinase complex
CCHDAGO:1903561extracellular vesicle
CCTASGO:1904813ficolin-1-rich granule lumen
BPIEAGO:0001666response to hypoxia
BPIEAGO:0001889liver development
BPIBAGO:0006096glycolytic process
BPIEAGO:0007584response to nutrient
BPIEAGO:0009629response to gravity
BPIDAGO:0012501programmed cell death
BPIEAGO:0014870response to muscle inactivity
BPIEAGO:0031100animal organ regeneration
BPIBAGO:0032869cellular response to insulin stimulus
BPTASGO:0043312neutrophil degranulation
BPIEAGO:0043403skeletal muscle tissue regeneration
BPIEAGO:0051289protein homotetramerization
BPTASGO:0061621canonical glycolysis

Gene expression in normal tissue: PKM

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PKM


DatabasePathway IDPathway Des.
kegghsa00010Glycolysis / Gluconeogenesis - Homo sapiens (human)
kegghsa00230Purine metabolism - Homo sapiens (human)
kegghsa00620Pyruvate metabolism - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
kegghsa04930Type II diabetes mellitus - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05230Central carbon metabolism in cancer - Homo sapiens (human)
humancycPWY66-400glycolysis
humancycPWY66-407superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
netpathPathway_EGFR1EGFR1
netpathPathway_TCRTCR
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-70171Glycolysis
reactomeR-HSA-70326Glucose metabolism
reactomeR-HSA-71387Metabolism of carbohydrates
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2003miR-targeted genes in leukocytes - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2006miR-targeted genes in squamous cell - TarBase
wikipathwaysWP3614Photodynamic therapy-induced HIF-1 survival signaling
wikipathwaysWP3925Amino Acid metabolism
wikipathwaysWP4018Pathways in clear cell renal cell carcinoma
wikipathwaysWP534Glycolysis and Gluconeogenesis
smpdbSMP00654Warburg Effect
pharmgkbPA166104634Abacavir Pathway, Pharmacokinetics/Pharmacodynamics
pidhif1_tfpathwayHIF-1-alpha transcription factor network

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011
iGMDRD125BIRB-7961
iGMDRD594AZD-80551
iGMDRD271Brefeldin A1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PKM

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