FLNA
Summary: The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| filamin A | MIM:300017 | Ensembl:ENSG00000196924 | HGNC:HGNC:3754 | PA28172 | Xq28 |
GO terms in FLNA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0001664 | G-protein coupled receptor binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0005515 | protein binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IDA | GO:0015459 | potassium channel regulator activity |
| MF | IDA | GO:0017048 | Rho GTPase binding |
| MF | IDA | GO:0017160 | Ral GTPase binding |
| MF | IPI | GO:0019900 | kinase binding |
| MF | IDA | GO:0031267 | small GTPase binding |
| MF | IEA | GO:0031852 | mu-type opioid receptor binding |
| MF | IDA | GO:0034988 | Fc-gamma receptor I complex binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0044325 | ion channel binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IEA | GO:0046332 | SMAD binding |
| MF | IDA | GO:0048365 | Rac GTPase binding |
| MF | IDA | GO:0051015 | actin filament binding |
| MF | IPI | GO:0051020 | GTPase binding |
| BP | TAS | GO:0002576 | platelet degranulation |
| BP | IMP | GO:0007195 | adenylate cyclase-inhibiting dopamine receptor signaling pathway |
| BP | IDA | GO:0016479 | negative regulation of transcription by RNA polymerase I |
| BP | IEA | GO:0021943 | formation of radial glial scaffolds |
| BP | IEA | GO:0021987 | cerebral cortex development |
| BP | TAS | GO:0030168 | platelet activation |
| BP | IDA | GO:0030334 | regulation of cell migration |
| BP | IDA | GO:0031532 | actin cytoskeleton reorganization |
| BP | IEA | GO:0032233 | positive regulation of actin filament bundle assembly |
| BP | TAS | GO:0034329 | cell junction assembly |
| BP | IDA | GO:0034394 | protein localization to cell surface |
| BP | IMP | GO:0042177 | negative regulation of protein catabolic process |
| BP | IEA | GO:0042789 | mRNA transcription by RNA polymerase II |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043113 | receptor clustering |
| BP | HMP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | IDA | GO:0044319 | wound healing, spreading of cells |
| BP | IDA | GO:0045184 | establishment of protein localization |
| BP | IMP | GO:0050821 | protein stabilization |
| BP | IMP | GO:0051220 | cytoplasmic sequestering of protein |
| BP | IDA | GO:0051764 | actin crosslink formation |
| BP | IMP | GO:0060271 | cilium assembly |
| BP | HMP | GO:0070527 | platelet aggregation |
| BP | IGI | GO:0071526 | semaphorin-plexin signaling pathway |
| BP | IDA | GO:0072659 | protein localization to plasma membrane |
| BP | IDA | GO:0090307 | mitotic spindle assembly |
| BP | IEA | GO:0097368 | establishment of Sertoli cell barrier |
| BP | IMP | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| BP | IDA | GO:1901381 | positive regulation of potassium ion transmembrane transport |
| BP | IEA | GO:1902396 | protein localization to bicellular tight junction |
| BP | IC | GO:1905000 | regulation of membrane repolarization during atrial cardiac muscle cell action potential |
| BP | ISS | GO:1905031 | regulation of membrane repolarization during cardiac muscle cell action potential |
| BP | IEA | GO:2000179 | positive regulation of neural precursor cell proliferation |
| BP | IMP | GO:2001046 | positive regulation of integrin-mediated signaling pathway |
| BP | IEA | GO:2001224 | positive regulation of neuron migration |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005634 | nucleus |
| CC | IMP | GO:0005730 | nucleolus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005911 | cell-cell junction |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IC | GO:0015629 | actin cytoskeleton |
| CC | IDA | GO:0015629 | actin cytoskeleton |
| CC | HDA | GO:0016020 | membrane |
| CC | ISS | GO:0030018 | Z disc |
| CC | IEA | GO:0030863 | cortical cytoskeleton |
| CC | IDA | GO:0031523 | Myb complex |
| CC | IDA | GO:0031941 | filamentous actin |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IEA | GO:0043198 | dendritic shaft |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IEA | GO:0097440 | apical dendrite |
Gene expression in normal tissue: FLNA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FLNA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3668 | Hypothesized Pathways in Pathogenesis of Cardiovascular Disease |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| pid | wnt_noncanonical_pathway | Noncanonical Wnt signaling pathway |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114608 | Platelet degranulation |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-430116 | GP1b-IX-V activation signalling |
| reactome | R-HSA-446353 | Cell-extracellular matrix interactions |
| reactome | R-HSA-446728 | Cell junction organization |
| reactome | R-HSA-5627123 | RHO GTPases activate PAKs |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD192 | CIL56 | 1 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD870 | BRD63610 | 6 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD584 | VER 155008 | 3 |
| iGMDRD607 | Ubistatin B | 3 |
| iGMDRD772 | BRD4770 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FLNA
CLASSFICATION
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