NEK2
Summary: This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:604043 Ensembl IDEnsembl:ENSG00000117650 HGNC IDHGNC:HGNC:7745 PHARMGKB IDPA31546 Map Location1q32.3 | |||||
GO terms in NEK2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IMP | GO:0004672 | protein kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019903 | protein phosphatase binding |
Gene expression in normal tissue: NEK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NEK2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | foxm1pathway | FOXM1 transcription factor network |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins |
| reactome | R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins |
| reactome | R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| reactome | R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NEK2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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