NEK2
Summary: This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| NIMA related kinase 2 | MIM:604043 | Ensembl:ENSG00000117650 | HGNC:HGNC:7745 | PA31546 | 1q32.3 |
GO terms in NEK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IMP | GO:0004672 | protein kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019903 | protein phosphatase binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IEA | GO:0000070 | mitotic sister chromatid segregation |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0000278 | mitotic cell cycle |
| BP | IEA | GO:0001824 | blastocyst development |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0007059 | chromosome segregation |
| BP | TAS | GO:0007088 | regulation of mitotic nuclear division |
| BP | TAS | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
| BP | IMP | GO:0032212 | positive regulation of telomere maintenance via telomerase |
| BP | IEA | GO:0043392 | negative regulation of DNA binding |
| BP | IMP | GO:0046602 | regulation of mitotic centrosome separation |
| BP | TAS | GO:0046602 | regulation of mitotic centrosome separation |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IMP | GO:0046777 | protein autophosphorylation |
| BP | TAS | GO:0051225 | spindle assembly |
| BP | IDA | GO:0051299 | centrosome separation |
| BP | IEA | GO:0051301 | cell division |
| BP | IEA | GO:0051321 | meiotic cell cycle |
| BP | IMP | GO:0051973 | positive regulation of telomerase activity |
| BP | IMP | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore |
| BP | IEA | GO:0090307 | mitotic spindle assembly |
| BP | TAS | GO:0097711 | ciliary basal body-plasma membrane docking |
| BP | IMP | GO:1903126 | negative regulation of centriole-centriole cohesion |
| BP | IMP | GO:1904355 | positive regulation of telomere capping |
| CC | IDA | GO:0000776 | kinetochore |
| CC | IDA | GO:0000776 | kinetochore |
| CC | IEA | GO:0000777 | condensed chromosome kinetochore |
| CC | IEA | GO:0000794 | condensed nuclear chromosome |
| CC | IEA | GO:0000922 | spindle pole |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005813 | centrosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005874 | microtubule |
| CC | IEA | GO:0030496 | midbody |
| CC | IMP | GO:0032991 | protein-containing complex |
Gene expression in normal tissue: NEK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NEK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | foxm1pathway | FOXM1 transcription factor network |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins |
| reactome | R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins |
| reactome | R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| reactome | R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A |
| reactome | R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-380259 | Loss of Nlp from mitotic centrosomes |
| reactome | R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes |
| reactome | R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome |
| reactome | R-HSA-380287 | Centrosome maturation |
| reactome | R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-453276 | Regulation of mitotic cell cycle |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620912 | Anchoring of the basal body to the plasma membrane |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-8854518 | AURKA Activation by TPX2 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD100 | Zebularine | 1 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD584 | VER 155008 | 1 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD297 | Austocystin D | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NEK2
CLASSFICATION
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