IGFBP7
Summary: This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| insulin like growth factor binding protein 7 | MIM:602867 | Ensembl:ENSG00000163453 | HGNC:HGNC:5476 | PA29709 | 4q12 |
Gene Categories:
DRUGGABLE GENOMEGO terms in IGFBP7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005520 | insulin-like growth factor binding |
| CC | HDA | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | HDA | GO:0062023 | collagen-containing extracellular matrix |
| CC | HDA | GO:0062023 | collagen-containing extracellular matrix |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0001558 | regulation of cell growth |
| BP | IDA | GO:0007155 | cell adhesion |
| BP | IEA | GO:0007566 | embryo implantation |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0009408 | response to heat |
| BP | IEA | GO:0032526 | response to retinoic acid |
| BP | IEA | GO:0032870 | cellular response to hormone stimulus |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IEA | GO:0050810 | regulation of steroid biosynthetic process |
| BP | IEA | GO:0051414 | response to cortisol |
Gene expression in normal tissue: IGFBP7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IGFBP7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-8957275 | Post-translational protein phosphorylation |
| wikipathways | WP3391 | Senescence-Associated Secretory Phenotype (SASP) |
| wikipathways | WP3670 | Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IGFBP7
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