NUDT11
Summary: NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002 [PubMed 12105228]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nudix hydrolase 11 | MIM:300528 | Ensembl:ENSG00000196368 | HGNC:HGNC:18011 | PA31832 | Xp11.22 |
GO terms in NUDT11
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0043647 | inositol phosphate metabolic process |
| BP | IBA | GO:0071543 | diphosphoinositol polyphosphate metabolic process |
| BP | IBA | GO:1901907 | diadenosine pentaphosphate catabolic process |
| BP | IBA | GO:1901909 | diadenosine hexaphosphate catabolic process |
| BP | IBA | GO:1901911 | adenosine 5'-(hexahydrogen pentaphosphate) catabolic process |
| CC | IDA | GO:0005622 | intracellular |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| MF | IBA | GO:0000298 | endopolyphosphatase activity |
| MF | IBA | GO:0008486 | diphosphoinositol-polyphosphate diphosphatase activity |
| MF | ISS | GO:0008486 | diphosphoinositol-polyphosphate diphosphatase activity |
| MF | IBA | GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| MF | IBA | GO:0034431 | bis(5'-adenosyl)-hexaphosphatase activity |
| MF | IBA | GO:0034432 | bis(5'-adenosyl)-pentaphosphatase activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IBA | GO:0050072 | m7G(5')pppN diphosphatase activity |
| MF | IEA | GO:0052840 | inositol diphosphate tetrakisphosphate diphosphatase activity |
| MF | TAS | GO:0052841 | inositol bisdiphosphate tetrakisphosphate diphosphatase activity |
| MF | TAS | GO:0052842 | inositol diphosphate pentakisphosphate diphosphatase activity |
| MF | IEA | GO:0052843 | inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity |
| MF | IEA | GO:0052844 | inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity |
| MF | IEA | GO:0052845 | inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity |
| MF | IEA | GO:0052846 | inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity |
| MF | IEA | GO:0052847 | inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity |
| MF | IEA | GO:0052848 | inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity |
Gene expression in normal tissue: NUDT11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NUDT11
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483249 | Inositol phosphate metabolism |
| reactome | R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD366 | PI-103 | 8 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD434 | BMS-536924 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NUDT11
CLASSFICATION
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