CASP9
Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| caspase 9 | MIM:602234 | Ensembl:ENSG00000132906 | HGNC:HGNC:1511 | PA26094 | 1p36.21 |
GO terms in CASP9
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0043293 | apoptosome |
| BP | IEA | GO:0006508 | proteolysis |
| BP | IBA | GO:0006915 | apoptotic process |
| BP | IMP | GO:0006915 | apoptotic process |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IEA | GO:0007568 | aging |
| BP | IBA | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| BP | IMP | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| BP | TAS | GO:0008635 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c |
| BP | TAS | GO:0030220 | platelet formation |
| BP | IEA | GO:0032025 | response to cobalt ion |
| BP | IEA | GO:0032355 | response to estradiol |
| BP | IEA | GO:0032496 | response to lipopolysaccharide |
| BP | IEA | GO:0034349 | glial cell apoptotic process |
| BP | IDA | GO:0034644 | cellular response to UV |
| BP | IDA | GO:0042770 | signal transduction in response to DNA damage |
| BP | IMP | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0043525 | positive regulation of neuron apoptotic process |
| BP | IEA | GO:0046677 | response to antibiotic |
| BP | IEA | GO:0071549 | cellular response to dexamethasone stimulus |
| BP | TAS | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| BP | IMP | GO:2001020 | regulation of response to DNA damage stimulus |
| MF | IDA | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008047 | enzyme activator activity |
| MF | IDA | GO:0008233 | peptidase activity |
| MF | IDA | GO:0017124 | SH3 domain binding |
| MF | IDA | GO:0019901 | protein kinase binding |
| MF | IBA | GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process |
Gene expression in normal tissue: CASP9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CASP9
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1433 | Nucleotide-binding Oligomerization Domain (NOD) pathway |
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP1984 | Integrated Breast Cancer Pathway |
| wikipathways | WP2059 | Alzheimers Disease |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2371 | Parkinsons Disease Pathway |
| wikipathways | WP2447 | Amyotrophic lateral sclerosis (ALS) |
| wikipathways | WP2507 | Nanomaterial induced apoptosis |
| wikipathways | WP2512 | Integrated Lung Cancer Pathway |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| wikipathways | WP384 | Apoptosis Modulation by HSP70 |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP3941 | Oxidative Damage |
| wikipathways | WP3981 | miRNA regulation of prostate cancer signaling pathways |
| wikipathways | WP3982 | miRNA regulation of p53 pathway in prostate cancer |
| wikipathways | WP4008 | NO-cGMP-PKG mediated Neuroprotection |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP707 | DNA Damage Response |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | pi3kciaktpathway | Class I PI3K signaling events mediated by Akt |
| pharmgkb | PA152241951 | Celecoxib Pathway, Pharmacodynamics |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04215 | Apoptosis - multiple species - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| kegg | hsa05012 | Parkinson,s disease - Homo sapiens (human) |
| kegg | hsa05014 | Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) |
| kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
| kegg | hsa05134 | Legionellosis - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| kegg | hsa05213 | Endometrial cancer - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05416 | Viral myocarditis - Homo sapiens (human) |
| biocarta | aktpathway | akt signaling pathway |
| biocarta | caspasepathway | caspase cascade in apoptosis |
| biocarta | chemicalpathway | apoptotic signaling in response to dna damage |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | hsp27pathway | stress induction of hsp regulation |
| biocarta | irespathway | internal ribosome entry pathway |
| biocarta | mitochondriapathway | role of mitochondria in apoptotic signaling |
| biocarta | plk3pathway | regulation of cell cycle progression by plk3 |
| biocarta | raspathway | ras signaling pathway |
| biocarta | tffpathway | trefoil factors initiate mucosal healing |
| biocarta | wnvpathway | west nile virus |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-111458 | Formation of apoptosome |
| reactome | R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage |
| reactome | R-HSA-111461 | Cytochrome c-mediated apoptotic response |
| reactome | R-HSA-111463 | SMAC binds to IAPs |
| reactome | R-HSA-111464 | SMAC-mediated dissociation of IAP:caspase complexes |
| reactome | R-HSA-111469 | SMAC-mediated apoptotic response |
| reactome | R-HSA-111471 | Apoptotic factor-mediated response |
| reactome | R-HSA-111471 | Apoptotic factor-mediated response |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168638 | NOD1/2 Signaling Pathway |
| reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| reactome | R-HSA-198323 | AKT phosphorylates targets in the cytosol |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-418889 | via Dependence Receptors in the absence of ligand |
| reactome | R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CASP9
CLASSFICATION
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