NFIA
Summary: This gene encodes a member of the NF1 (nuclear factor 1) family of transcription factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nuclear factor I A | MIM:600727 | Ensembl:ENSG00000162599 | HGNC:HGNC:7784 | PA31590 | 1p31.3 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in NFIA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006260 | DNA replication |
| BP | NAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | NAS | GO:0019079 | viral genome replication |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0060074 | synapse maturation |
| BP | IEA | GO:0072189 | ureter development |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | NAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0030054 | cell junction |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0003682 | chromatin binding |
| MF | NAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0008134 | transcription factor binding |
Gene expression in normal tissue: NFIA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NFIA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| pid | hnf3apathway | FOXA1 transcription factor network |
| reactome | R-HSA-73980 | RNA Polymerase III Transcription Termination |
| reactome | R-HSA-74158 | RNA Polymerase III Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD434 | BMS-536924 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NFIA
CLASSFICATION
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