EIF2B5
Summary: This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| eukaryotic translation initiation factor 2B subunit epsilon | MIM:603945 | Ensembl:ENSG00000145191 | HGNC:HGNC:3261 | PA27692 | 3q27.1 |
Gene Categories:
DRUG RESISTANCEGO terms in EIF2B5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0001541 | ovarian follicle development |
| BP | IDA | GO:0006413 | translational initiation |
| BP | IEA | GO:0007568 | aging |
| BP | IMP | GO:0009408 | response to heat |
| BP | ISS | GO:0009408 | response to heat |
| BP | TAS | GO:0009408 | response to heat |
| BP | ISS | GO:0009749 | response to glucose |
| BP | IEA | GO:0010226 | response to lithium ion |
| BP | IMP | GO:0014002 | astrocyte development |
| BP | IMP | GO:0014003 | oligodendrocyte development |
| BP | IEA | GO:0021766 | hippocampus development |
| BP | IMP | GO:0034976 | response to endoplasmic reticulum stress |
| BP | IMP | GO:0042552 | myelination |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
| BP | ISS | GO:0043434 | response to peptide hormone |
| BP | ISS | GO:0045948 | positive regulation of translational initiation |
| BP | IMP | GO:0048708 | astrocyte differentiation |
| BP | IDA | GO:0050852 | T cell receptor signaling pathway |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005851 | eukaryotic translation initiation factor 2B complex |
| CC | IDA | GO:0005851 | eukaryotic translation initiation factor 2B complex |
| MF | IBA | GO:0003743 | translation initiation factor activity |
| MF | IDA | GO:0003743 | translation initiation factor activity |
| MF | NAS | GO:0003743 | translation initiation factor activity |
| MF | IBA | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | IDA | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | IMP | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | ISS | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0031369 | translation initiation factor binding |
| MF | ISS | GO:0031369 | translation initiation factor binding |
Gene expression in normal tissue: EIF2B5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EIF2B5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-72613 | Eukaryotic Translation Initiation |
| reactome | R-HSA-72731 | Recycling of eIF2:GDP |
| reactome | R-HSA-72737 | Cap-dependent Translation Initiation |
| reactome | R-HSA-72766 | Translation |
| biocarta | eif2pathway | regulation of eif2 |
| biocarta | igf1mtorpathway | skeletal muscle hypertrophy is regulated via akt-mtor pathway |
| kegg | hsa03013 | RNA transport - Homo sapiens (human) |
| wikipathways | WP107 | Translation Factors |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD945 | ML214 | 6 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD105 | Triptolide | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EIF2B5
CLASSFICATION
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