EIF2B5
Summary: This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603945 Ensembl IDEnsembl:ENSG00000145191 HGNC IDHGNC:HGNC:3261 PHARMGKB IDPA27692 Map Location3q27.1 | |||||
Gene Categories:
DRUG RESISTANCEGO terms in EIF2B5
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0001541 | ovarian follicle development |
| BP | IDA | GO:0006413 | translational initiation |
| BP | IEA | GO:0007568 | aging |
| BP | IMP | GO:0009408 | response to heat |
| BP | ISS | GO:0009408 | response to heat |
| BP | TAS | GO:0009408 | response to heat |
Gene expression in normal tissue: EIF2B5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EIF2B5
Loading, please wait...
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-72613 | Eukaryotic Translation Initiation |
| reactome | R-HSA-72731 | Recycling of eIF2:GDP |
| reactome | R-HSA-72737 | Cap-dependent Translation Initiation |
| reactome | R-HSA-72766 | Translation |
| biocarta | eif2pathway | regulation of eif2 |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EIF2B5
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.